 | | Vol. 7.23 – 30 June, 2023 |
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| Proteomic profiling of circulating small extracellular vesicles of control individuals and HCC patients identified von Willibrand factor (vWF) to be upregulated progressively along HCC stages.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By using APOE*3-Leiden. CETP mice, researchers reported that SH42 markedly increased desmosterol levels in liver and plasma, reduced hepatic lipid content and the steatosis score, and decreased plasma fatty acid and cholesteryl ester concentrations.
[EMBO Molecular Medicine] |
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| To elucidate the unique mode of Wnt signaling in HCC, scientists comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1.
[Cancer Research] |
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| The authors investigated the therapeutic potential of Orosomucoid 2, an acute phase protein predominantly secreted by hepatocytes, for treating non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
[Cell Reports] |
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| Mechanistically, aggravated tumorigenesis upon Mettl3 deletion was a consequence of hepatocyte dedifferentiation and hyperproliferation via N6-methyladenosine-mediated modulation on Hnf4α and cell cycle genes.
[Cell Reports] |
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| To investigate the impact of neuronal regeneration-related protein (NREP) insufficiency, scientists used RNA-sequencing, lipidomics, and antibody microarrays on primary human hepatocytes.
[Cell Chemical Biology] |
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| For the detection of proteins, liver cancer tissue microarrays were analyzed by immunohistochemistry. Liver cancer cell lines were used for viability, proliferation, and migration analyses after RNAinterference-mediated gene silencing.
[Cell Communication and Signaling] |
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| Investigators explored whether and how Krüppel-like factor 14 affected hepatic lipid metabolism in nonalcoholic steatohepatitis (NASH). KLF14 expression was detected in NASH patients and mice fed a choline-deficient, L-amino acid-defined, high-fat diet.
[FASEB Journal] |
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| Liver tissue microarrays containing steatotic livers from donors with or without a history of alcohol consumption were used to measure hyaluronan and collagen content.
[Alcoholism-Clinical And Experimental Research] |
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| The authors translate the improved understanding of tumor-specific, location-specific, and stage-specific roles of fibroblasts and their mediators in liver cancer into novel and rational therapeutic concepts.
[Lancet Gastroenterology and Hepatology] |
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| Scientists provide direction for future research on combating hepatic ischemia-reperfusion injury by reviewing the latest studies that focus on targeting mitochondrial quality control mechanisms.
[Heliyon] |
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| McMaster University has received $6.8M from the federal government as part of a national initiative to create a Canadian Medical Isotope Ecosystem – a pan-Canadian network for medical isotope research and innovation.
[McMaster University] |
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| August 6 – 11, 2023
Newry, Maine, United States |
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| | The National University of Singapore – Singapore, Singapore |
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| | Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | Scripps Research – La Jolla, California, United States |
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| | University of Southern Denmark – Odense, Denmark |
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| | Springer Nature Ltd – New York City, New York, United States |
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