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| The authors showed that by increasing lysosomal exocytosis, transient receptor potential mucolipin 1 (TRPML1) gene transfer or small molecule-mediated activation of TRPML1 reduced hepatic mutant Z-alpha-1 antitrypsin (ATZ) globules and fibrosis in PiZ transgenic mice that expressed the human ATZ.
[Molecular Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators fed C57BL6/J mice one of three diets, a standard chow diet, high-sucrose diet, or high-fat diet, and then characterized them. The mice fed a high-sucrose diet had more severely compacted macrovesicular and microvesicular lipid droplets than those in the other groups.
[Experimental & Molecular Medicine] |
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| Researchers observed that deubiquitinase USP15 expression was upregulated in the livers of mice fed a high-fat diet and liver biopsies of patients with nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
[Experimental & Molecular Medicine] |
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| The authors explored the lipid accumulation and metabolic processes of the Himalayan marmot, a hibernating rodent species. They found that the unsaturated fatty acid (UFA) content in food was consistent with a large increase in the body mass of Himalayan marmots.
[Cell Reports] |
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| After ischemia-reperfusion (I/R) injury, scientists found that Krüppel-like factor (KLF) 6 expression in mice and hepatocytes was significantly upregulated. Mice were then subjected to I/R following injection of shKLF6- and KLF6-overexpressing adenovirus through the tail vein.
[Cell Death & Disease] |
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| Researchers investigated the role and mechanism of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) in regulating cancer stem cell properties and evaluated the impact of UHRF1 targeting on HCC.
[Cell Death & Disease] |
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| Investigators tested 14 flavones/isoflavones in hepatocytes using dual luciferase reporter system based on the Nogo-B transcriptional response system, and found that 6-methyl flavone exerted the strongest inhibition on Nogo-B expression in hepatocytes.
[Acta Pharmacologica Sinica] |
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| Analyses of liver tissue samples from severe alcoholic hepatitis patients and two murine models of alcoholic liver disease (ALD) revealed that the ALD phenotype was associated with upregulation of ETS domain-containing protein (ELK-3) and ELK-3 signaling activity.
[Communications Biology] |
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| Scientists generated quiescent-like hepatic stellate cells (iqHSCs) from human induced pluripotent stem cells and developed a culture method to maintain such iqHSCs in a lowly activated state for up to five days by optimizing their physical culture microenvironment.
[Biotechnology and Bioengineering] |
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| Lifestyle interventions, including diet and physical activity, are the main treatments for nonalcoholic fatty liver disease. The Mediterranean diet, or a diet similar in its culturally sensitive components, is the most effective diet for losing weight.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors summarize the metabolic characteristics of the development of nonalcoholic fatty liver disease (NAFLD), including glucose metabolism, lipid metabolism, and intestinal metabolism, and provide insight into pharmacological targets.
[Nutrition & Metabolism] |
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| Dr. Grant Pierce was appointed Member of the Order of Canada for his contributions as a distinguished professor of physiology and pathophysiology at the Max Rady College of Medicine
[University of Manitoba] |
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| Sano Genetics, Predictive Health Intelligence, and Somerset NHS Foundation Trust will be collaborating with Tawazun Health, specialists in mobile non-invasive liver scanning technology.
[Sano Genetics] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | BC Cancer Center – Vancouver, British Columbia, Canada |
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| | The National University of Singapore – Singapore, Singapore |
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| | Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | University of Southern Denmark – Odense, Denmark |
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