 | | Vol. 7.25 – 14 July, 2023 |
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| Researchers engineered a synthetic adaptor protein to induce lipophagy, combining a lipid droplet-targeting signal with an optimized LC3-interacting domain. Activating hepatocyte lipophagy in vivo strongly mitigated both steatosis and hepatitis in a diet-induced mouse nonalcoholic steatohepatitis model.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In vivo and in vitro experiments revealed that SOR@TF-Fe3+ nanovesicles predominantly accumulate in the liver, and specifically targeted HCC cells overexpressing transferrin receptor.
[Biomaterials Research] |
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| Researchers defined the key molecule hyaluronan-mediated motility receptor (HMMR) in this process and explore its role under endoplasmic reticulum stress in HCC development.
[Cancer Communications] |
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| Based on the proteomic profiles of HCC in the patient cohort, scientists found that Lysozyme (LYZ) had opposite expression patterns between tumor and paracancerous tissues in patients of different subtypes of HCC and that high LYZ abundance in HCC tissues predicted poor prognosis in patients.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The expression pattern and clinical correlation of PD-L1 and PD-1 were analyzed in 5245 primary liver cancer (PLC) patients. The positivity rates of PD-L1 and PD-1 were very low in the patient PLCs.
[Liver International] |
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| Investigators studied the influence of exogenous Hydrogen sulfide (H2S) on nonalcoholic fatty liver disease (NAFLD) and its potential mechanism. In vivo, NAFLD model was induced by high-fat diet for 12 weeks, followed by intraperitoneal injection of exogenous H2S intervention for four weeks.
[FASEB Journal] |
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| Scientists took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes.
[Epigenetics & Chromatin] |
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| Nosip expression was found to be elevated in HCC tissues and cells. Nosip siRNA transfection inhibited the proliferation and motility of HCC cells and promoted apoptosis.
[iScience] |
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| Researchers explored the mechanism and role of Heme oxygenase 1 in nonalcoholic steatohepatitis ferroptosis. Hepatic steatosis, inflammation, fibrosis, lipid peroxidation, and iron overload were assessed. AML12 and HepG2 cells were used to investigate the underlying mechanisms in vitro.
[Lipids in Health and Disease] |
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| Bioinformatics analyses combined with in vitro and in vivo assays were used to identify the potential therapeutic targets. Differentially expressed genes in HCC were identified by the intersection between The Cancer Genome Atlas and International Cancer Genome Consortium data.
[BMC Cancer] |
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| Scientists investigated unique expression profiles of circRNAs in HCC and identify novel biomarkers associated with HCC development and progression. Overexpression plasmid and siRNA targeting candidate circRNAs were used in functional assays in vitro.
[BMC Cancer] |
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| Researchers explored the role and mechanism of circ_0088046 in HCC progression. Quantitative real-time polymerase chain reaction, western blot and immunohistochemistry assays were used to detect the mRNA and protein expression of circ_0088046, miR-1299, Rhotekin 2 (RTKN2), Bax, Bcl-2, E-cadherin and Ki-67.
[Journal of Viral Hepatitis] |
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| RNA methylated methyltransferase, demethylase, and reading protein extensively affect the pathological mechanism of hepatic fibrosis, which may be a new therapeutic and diagnostic target, representing a new class of therapeutic strategies.
[Cell & Bioscience] |
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| The authors review the research on HCC treatment based on siRNA in recent years, and summarizes and classify the HCC treatment targets and siRNA delivery systems.
[Journal of Gastrointestinal Cancer] |
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| Researchers from the UCLA Jonsson Comprehensive Cancer Center received a $3.3 million grant from the National Institutes of Health to find a more effective way to detect hepatocellular carcinoma, the most common type of liver cancer, which often has a poor prognosis.
[UCLA Health] |
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| August 3, 2023
New York, New York, United States |
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| | National Institute of Health – Bethesda, Maryland, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | BC Cancer Center – Vancouver, British Columbia, Canada |
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| | The National University of Singapore – Singapore, Singapore |
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| | Joslin Diabetes Center – Boston, Massachusetts, United States |
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