Hepatic Cell News Volume 7.26 | Jul 21 2023

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    Noshin Noorjahan
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    2023-07-21 | HCN 7.26


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.26 – 21 July, 2023
    TOP STORY

    GDF15 Increases Insulin Action in the Liver and Adipose Tissue via a β-Adrenergic Receptor-Mediated Mechanism

    Obese rats were treated with growth differentiation factor 15 (GDF15) and displayed increased insulin tolerance five hours later. Lean and obese female and male mice were treated with GDF15 on days one, three, and five without weight loss.
    [Cell Metabolism]

    AbstractGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Mechanical Confinement Promotes Heat Resistance of Hepatocellular Carcinoma via SP1/IL4I1/AHR Axis

    By developing a 3D bioprinting-based thermal ablation system, researchers demonstrated that HCC cells in this 3D model exhibited enhanced heat resistance as compared with cells on plates.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Wnt Signaling Stimulates Cooperation Between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma

    To elucidate the unique mode of Wnt signaling in HCC, scientists comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1.
    [Cancer Research]

    Abstract

    Elevated FBXW10 Drives Hepatocellular Carcinoma Tumorigenesis via AR-VRK2 Phosphorylation-Dependent GAPDH Ubiquitination in Male Transgenic Mice

    Investigators reported that ubiquitinated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was responsible for HCC tumorigenesis in males. Mechanistically, F box and WD repeat domain containing 10 (FBXW10) promoted GAPDH polyubiquitination and activation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Exosomal circTGFBR2 Promotes Hepatocellular Carcinoma Progression via Enhancing ATG5 Mediated Protective Autophagy

    The authors focused on circRNAs enriched in starvation-stressed hepatocytic exosomes and further investigated their function and mechanism in HCC progression.
    [Cell Death & Disease]

    Full Article

    An Extended Transcription Factor Regulatory Network Controls Hepatocyte Identity

    By mining global hepatic transcription factor regulons, scientists revealed a more complex organization of the transcriptional regulatory network controlling hepatocyte identity.
    [EMBO Reports]

    AbstractGraphical Abstract

    TAF1B Depletion Leads to Apoptotic Cell Death via Inducing Nucleolar Stress and Activating p53-miR-101 Circuit in Hepatocellular Carcinoma

    Investigators analyzed the differential expression and prognostic value of TATA Box Binding Protein (TBP)-Associated Factor (TAF1B) in HCC based on the TCGA database, tumor and paraneoplastic tissue samples from clinical HCC patients, and typical hepatocellular carcinoma.
    [Frontiers in Oncology]

    Abstract

    m6A Reader YTHDF3 Triggers the Progression of Hepatocellular Carcinoma through the YTHDF3/m6A-EGFR/STAT3 Axis and EMT

    Researchers investigated the oncogenic effect of YTHDF3 on HCC progression via the epigenetic regulation of N6-methyladenosine (m6A)-modified mRNAs.
    [Molecular Carcinogenesis]

    Abstract

    Phytochemical Profiling and Cytotoxic Potential of Arnebia nobilis Root Extracts against Hepatocellular Carcinoma Using In Vitro and In Silico Approaches

    The authors deciphered the Arnebia nobilis extracts for detecting phytochemicals, in vitro evaluation of antioxidative and cytotoxic potentials, and in silico prediction of potent anticancer compounds.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Decoding Hepatocarcinogenesis from a Noncoding RNAs Perspective

    Scientists shed light on future trends, thereby discussing the pathological roles of lncRNAs and circRNAs in HCC proliferation, migration, and epithelial-to-mesenchymal transition.
    [Journal Of Cellular Physiology]

    Abstract

    Cellular Heterogeneity and Plasticity during NAFLD Progression

    Investigators provided insights into non-alcoholic fatty liver disease (NAFLD) heterogeneity by addressing cellular plasticity and metabolic adaptation of hepatocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.
    [Frontiers in Molecular Biosciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    VBI Vaccines Announces PreHevbri® is Now Available in the Netherlands and Belgium for the Prevention of Hepatitis B in Adults

    VBI Vaccines Inc. announced that PreHevbri® is now available in the Netherlands and Belgium for active immunization against infection caused by all known subtypes of the hepatitis B virus in adults.
    [VBI Vaccines]

    Press Release
    FEATURED EVENT

    AFLAS Congress 2023

    September 13 – 15, 2023
    Seogwipo, South Korea

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Gastroenterology & Hepatology

    Weill Cornell Medicine Gastroenterology – New York City, New York, United States

    Staff Scientist – Viral Hepatitis, HCC

    National Institute of Health – Bethesda, Maryland, United States

    Postdoctoral Associate – Obesity, Adipose Tissue, and Metabolism

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Metabolism & NAFLD

    Joslin Diabetes Center – Boston, Massachusetts, United States

    Associate or Senior Editor – Nature Metabolism

    Springer Nature Ltd – New York City, New York, United States

    > See All Jobs

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