 | | Vol. 7.27 – 28 July, 2023 |
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| Using RNA-seq and CUT&Tag chromatin profiling, researchers found that induction of hexokinase 2 expression in activated hepatic stellate cells was required for induced gene expression by histone lactylation but not histone acetylation.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Through comparative mouse proteomics, investigators found that fasting induced strain-specific mitochondrial cristae formation in the liver by upregulating MIC19, a subunit of the MICOS complex.
[Cell Metabolism] |
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| The authors established a patient-derived liver cancer organoid biobank that comprehensively represented the histological and molecular characteristics of various liver cancer types as determined by multiomics profiling, including genomic, epigenomic, transcriptomic, and proteomic analysis.
[Science Translational Medicine] |
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| Scientists investigated the effects of oxidative stress on hepatic encephalopathy (HE) in male mice. The results validated the existence of oxidative stress in both liver and substantia nigra pars reticulata across two murine models of HE induced by thioacetamide and bile duct ligation.
[Nature Communications] |
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| Researchers discovered that promoter-associated histone modifications and chromatin accessibility dynamics, rather than enhancer-associated histone modifications, effectively delineated the “default vs. directed” process of hepatoblast differentiation.
[Developmental Cell] |
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| Investigators explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protected against fasting- and diabetes-mediated hepatic glucose metabolism.
[Experimental & Molecular Medicine] |
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| Scientists established a multivariate cox proportional hazards model for the risk of incident liver disease during an 11 year follow up time.
[Frontiers in Public Health] |
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| Lipopolysaccharide and cecum ligation and puncture were utilized to establish an inflammatory cell model and a murine model of sepsis-induced liver injury.
[Scientific Reports] |
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| Using three HCC cell lines, the effects of pelitinib on cell cytotoxicity, invasion, and migration were determined by cell viability, wound healing, transwell invasion, and spheroid invasion assays.
[BMC Cancer] |
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| The authors summarize the changes or mutations in the activity of splicing factors in non-alcoholic fatty liver disease (NAFLD) and HCC, as well as the impact of alternative splicing mediated by epigenetic modifications such as DNA methylation and RNA methylation on liver cell fate.
[Trends in Molecular Medicine] |
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| Mexico’s controversial new science law, which seeks to reshape government research funding and governance, is facing a flurry of legal challenges.
[SCIENCEINSIDER] |
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| September 20 – 23, 2023
Milan, Italy |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | NICHD – Bethesda, Maryland, United States |
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| | Weill Cornell Medicine Gastroenterology – New York City, New York, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Joslin Diabetes Center – Boston, Massachusetts, United States |
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