 | | Vol. 7.28 – 4 August, 2023 |
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| Researchers showed that in mice, hepatic S-adenosylmethionine—the principal methyl donor—acted as a metabolic sensor of nutrition to fine-tune the catabolic-fasting response.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators studied how alternative splicing of Ceacam1 affected ischemia-reperfusion injury (IRI) in mouse and human livers. They found that the short cytoplasmic isoform Ceacam1-S increased during early acute and late resolution phases of warm IRI injury in mice.
[Science Translational Medicine] |
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| Scientists explored the role of CAND1 in the development of nonalcoholic fatty liver disease (NAFLD) and the underlying mechanisms. CAND1 was reduced in the liver of NAFLD male patients and high fat diet -fed male mice.
[Nature Communications] |
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| The authors uncovered that enolase 1 (ENO1), as an RNA-binding protein, bound to the cytosine-uracil-guanine-rich elements of YAP1 messenger RNA to promote its translation.
[Nature Chemical Biology] |
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| Investigators demonstrated that the hepatic expression level of thyroid hormone receptor-associated protein 3 (Thrap3) was significantly increased in nonalcoholic fatty liver disease conditions.
[Experimental & Molecular Medicine] |
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| Researchers confirmed the upregulation of hexokinase 2 (HK2) in HCC tissue and demonstrated that HK2 exerteed a radio-resistant role by attenuating apoptosis and promoting proliferation in HCC cell lines.
[Cell Death & Disease] |
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| Scientists discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor prognosis.
[Cell Death & Disease] |
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| The authors provided an agent for therapy for late-stage liver injury induced by acetaminophen, exhibiting a superior effect to the FDA-approved drug, N-acetylcysteine.
[Materials & Design] |
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| Investigators reported a novel use of a medium designed for induced pluripotent stem cell-derived hepatocytes, increasing primary human hepatocyte attachment on the collagen matrix.
[Scientific Reports] |
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| The authors comprehensively summarize and discuss the advantages and disadvantages, rationale, current status, and progress of pig models for liver cancer research.
[Biomedicine & Pharmacotherapy] |
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| Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
[Science Insider] |
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| September 28 – 30, 2023
New York, New York, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | NICHD – Bethesda, Maryland, United States |
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| | Weill Cornell Medicine Gastroenterology – New York City, New York, United States |
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