 | | Vol. 7.29 – 11 August, 2023 |
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| Using chemical libraries derived from clinical multi-kinase inhibitor (KI) scaffolds, investigators screened HCC organoids to identify WNTinib, a KI with exquisite selectivity in CTNNB1-mutated human and murine models, including patient samples.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that inactive rhomboid protein 2 (IRHOM2) was post-translationally S-palmitoylated at C476 in iRhom homology domain, which facilitated its cytomembrane translocation and stabilization.
[Advanced Science] |
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| Scientists proposed the use of gelatin-hyaluronic acid (Gel-HA) scaffolds seeded with primary human hepatocytes for the treatment of liver failure. They first optimized the composition using Gel-HA hydrogels, looking for the mechanical properties closer to the human liver and determining HepG2 cells functionality.
[Biomaterials Advances] |
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| The authors performed scRNA-seq and snRNA-seq to explore the precise hepatocyte development process in mice. They defined three maturation stages of postnatal hepatocytes, each of which established specific metabolic functions and exhibited distinct proliferation rates.
[Developmental Cell] |
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| Researchers analyzed the altered expression level and clinical significance of CCDC137 in database and HCC specimens. In vitro cell assays and in vivo spontaneous mouse models were used to assess the function of CCDC137.
[Journal of Experimental & Clinical Cancer Research] |
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| Hepatic hsa-miR-21-5p expression was evaluated in two cohorts of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) or HCC . Serum/liver metabolomic profiles were correlated with hsa-miR-21-5p in NAFLD obese patients.
[Liver International] |
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| Investigators reported that hsa_circ_0000647 (circSEC11A) was highly expressed after I-125 treatment in HCC cell lines and tissues and was a key regulator of I-125-induced anticancer effects.
[Cell Death Discovery] |
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| Scientists investigated the potential role of miR-871-5p in regulating hepatic lipid deposition associated with aging. They performed in vitro transfection of both miR-871-5p mimic and inhibitor into senescent hepatocytes.
[Journals Of Gerontology Series A-Biological Sciences And Medical Sciences] |
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| Researchers used zebrafish to investigate the effects of apatinib on the development of embryos. Zebrafish exposed to 2.5, 5, and 10 μM apatinib showed adverse effects such as decreased liver area, pericardial oedema, slow yolk absorption, bladder atrophy, and body length shortening.
[Environmental Toxicology] |
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| The authors revealed the underlying mechanisms of 6-methoxydihydrosanguinarine (6-MS)-induced cytotoxicity in HCC cells and investigated whether 6-MS sensitized TNF-related apoptosis inducing ligand-induced apoptosis.
[Medical Oncology] |
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| Scientists review the transcriptomic and functional similarities between hepatic stellate cell and cancer-associated fibroblast subpopulations, highlighting the pathways that either promote or prevent fibrosis and cancer, and the immunological landscape from which these pathways emerge.
[Nature Reviews Gastroenterology & Hepatology] |
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| Understanding of nonalcoholic fatty liver disease (NAFLD)-specific hepatocarcinogenesis and HCC would enable us to improve the current daily practice and eventually the prognoses of patients with NAFLD.
[Cancer Science] |
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| New York University Abu Dhabi (NYUAD) Professor of Biology Kirsten Sadler Edepli has been awarded a Research Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study aging with a focus on understanding how the liver loses its capacity to regenerate over time.
[New York University Abu Dhabi] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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