Hepatic Cell News Volume 7.30 | Aug 18 2023

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    Noshin Noorjahan
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    2023-08-18 | HCN 7.30


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.30 – 18 August, 2023
    TOP STORY

    Hyodeoxycholic Acid Alleviates Non-Alcoholic Fatty Liver Disease through Modulating the Gut-Liver Axis

    Researchers reported that a group of gut microbiota-modified bile acids, hyodeoxycholic acid species, were negatively correlated with the presence and severity of non-alcoholic fatty liver disease.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    METTL3 Drives NAFLD-Related Hepatocellular Carcinoma and Is a Therapeutic Target for Boosting Immunotherapy

    Single-cell RNA sequencing revealed that METTL3 suppressed antitumor immune response by reducing granzyme B and interferon gamma-positive CD8+ T cell infiltration, thereby facilitating immune escape.
    [Cell Reports Medicine]

    Full Article

    GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling

    Mdr2-/- mice were injected daily for four weeks with teduglutide followed by gene expression profiling and immunohistochemistry.
    [Cellular and Molecular Gastroenterology and Hepatology]

    Abstract

    CD58 Acts as a Tumor Promotor in Hepatocellular Carcinoma via Activating the AKT/GSK-3β/β-Catenin Pathway

    Immunohistochemical staining and western blotting were used to detect the expression of CD58 in HCC tissues and cells. The levels of a soluble form of CD58 in the cell supernatants and serum were assessed by ELISA.
    [Journal of Translational Medicine]

    Full ArticleGraphical Abstract

    A Novel Hepatocellular Carcinoma-Specific mTORC1-Related Signature for Anticipating Prognosis and Immunotherapy

    Mammalian target of the rapamycin complex 1 (mTORC1) scores were computed employing a single sample gene set enrichment analysis based on databases including the International Cancer Genome Consortium and The Cancer Genome Atlas.
    [Aging-Us]

    Full Article

    Sphingomyelin Synthase–Related Protein SMSr Is a Phosphatidylethanolamine Phospholipase C Protein that Promotes Nonalcoholic Fatty Liver Disease

    Investigators evaluated high-fat diet/fructose-induced nonalcoholic fatty liver disease in sphingomyelin synthase–related protein (Smsr) knock out and WT mice.
    [Journal Of Biological Chemistry]

    Full Article

    Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a N-Nitrosodiethylamine-Induced Mice Model of Hepatocellular Carcinoma

    The authors enhanced telmisartan’s liver uptake for HCC management through passive and active targeting pathways utilizing chitosan nanoparticles decorated with lactose as a delivery system.
    [Molecular Pharmaceutics]

    AbstractGraphical Abstract

    miR-9-5p Expression Is Associated with Vascular Invasion and Prognosis in Hepatocellular Carcinoma, and In Vitro Verification

    Differential expression analysis of miRNAs related to vascular invasion was performed based on data from the TCGA database, and survival-associated miRNAs identified.
    [Journal of Cancer Research and Clinical Oncology]

    AbstractGraphical Abstract
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    REVIEWS

    The Intersection between Alcohol-Related Liver Disease and Nonalcoholic Fatty Liver Disease

    Scientists analyze existing data on the interaction between alcohol consumption and metabolic syndrome as well as the overlapping features and differences in the pathogenesis of alcohol-related liver disease and nonalcoholic fatty liver disease.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Nuvectis Pharma Announces Orphan Drug Designation Granted by the FDA to NXP800 for the Treatment of Cholangiocarcinoma

    Nuvectis Pharma, Inc. announced that NXP800 was granted Orphan Drug Designation by the US FDA for the treatment of cholangiocarcinoma.
    [Nuvectis Pharma]

    Press Release
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    Creative Biolabs – New York, New York, United States

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    Cedars-Sinai – Los Angeles, California, United States

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