Hepatic Cell News Volume 7.32 | Sept 01 2023

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    Noshin Noorjahan
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    2023-09-01 | HCN 7.32


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.32 – 01 September, 2023
    TOP STORY

    Impact of PNPLA3I148M on Alpha-1 Antitrypsin Deficiency-Dependent Liver Disease Progression

    After generating transgenic mice that overexpressed the PiZ variant and simultaneously harbored the patatin-like phospholipase domain-containing protein 3 (PNPLA3)I148M knockin, scientists observed that PiZ and PiZ/PNPLA3I148M animals showed increased liver enzymes during aging.
    [Hepatology]

    AbstractGraphical Abstract
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    PUBLICATIONSRanked by the impact factor of the journal

    Expression of Cyclin E1 in Hepatic Stellate Cells Is Critical for the Induction and Progression of Liver Fibrosis and Hepatocellular Carcinoma in Mice

    Researchers examined the role of cyclin E1 and Cdk2 genes in hepatic stellate cells for liver fibrogenesis and hepatocarcinogenesis.
    [Cell Death & Disease]

    Full Article

    Hepatocyte-Specific Sox9 Knockout Ameliorates Acute Liver Injury by Suppressing SHP Signaling and Improving Mitochondrial Function

    Investigators developed the mature hepatocyte-specific sex determining region Y related high-mobility group box protein 9 (Sox9) knockout mouse line and applied three acute liver injury models including partial hepatectomy, CCl4, and hepatic ischemia reperfusion.
    [Cell & Bioscience]

    Full ArticleGraphical Abstract

    Hydronidone Ameliorates Liver Fibrosis by Inhibiting Activation of Hepatic Stellate Cells via Smad7-Mediated Degradation of TGFβRI

    The anti-hepatic fibrosis effects of hydronidone were studied in carbon tetrachloride- and 3,5-diethoxycarbonyl-1,4-dihydrocollidine- induced animal liver fibrosis.
    [Liver International]

    Full Article

    The PKA-SREBP1c Pathway Plays a Key Role in the Protective Effects of Lactobacillus johnsonii JNU3402 against Diet-Induced Fatty Liver in Mice

    Seven-week-old male mice were fed a high-fat diet with or without oral supplementation of Lactobacillus johnsonii JNU3402 for 14 weeks.
    [Molecular Nutrition & Food Research]

    Abstract

    ZBTB34 Is a Hepatocellular Carcinoma-Associated Protein with a Monopartite Nuclear Localization Signal

    According to the bioinformatics analysis and qPCR results, liver hepatocellular carcinomas exhibited a high level of zinc finger protein 34 (ZBTB34) expression.
    [Aging]

    Full Article

    Novel VEGFR2 Inhibitors with Thiazoloquinoxaline Scaffold Targeting Hepatocellular Carcinoma with Lower Cardiotoxic Impact

    Ten novel thiazoloquinoxaline derivatives coupled with different sulfonamide moieties were designed and synthesized fulfilling pharmacophoric features of vascular endothelial growth factor receptor (VEGFR)-2 inhibition.
    [Scientific Reports]

    Full Article

    Single-Cell RNA Sequencing to Detect Age-Associated Genes That Identify Senescent Cells in the Liver of Aged Mice

    Investigators searched for age-associated genes to identify senescent cells in the livers of aged animals. They performed scRNA-seq to screen candidates for age-associated genes using young and aged rat primary hepatocytes.
    [Scientific Reports]

    Full Article

    Phosphorylation of RasGRP1 by Shc3 Prevents RasGRP1 Degradation and Contributes to Ras/c-Jun Activation in Hepatocellular Carcinoma

    The authors reported that RasGRP1 physically interacted with the adaptor protein Src homolog and collagen homolog 3 (Shc3).
    [Molecular and Cellular Biochemistry]

    Abstract

    Kinesin Family Member 11 Promotes Progression of Hepatocellular Carcinoma via the OCT4 Pathway

    Scientists evaluated the potential role of kinesin family (KIF) 11 in HCC. The effect of KIF11 was evaluated using the hepatocellular carcinoma cell lines, LM3 and Huh7, after genetic or pharmacological treatment.
    [Functional & Integrative Genomics]

    Abstract

    Toll-Interacting Protein May Affect Doxorubicin Resistance in Hepatocellular Carcinoma Cell Lines

    The NIH Gene Expression Omnibus and Oncomine datasets were analyzed for HCC cell lines with relatively low and high toll-interacting protein expression, and SNU449 and Hep3B cell lines were chosen, respectively.
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    The Extracellular Matrix in Hepatocellular Carcinoma: Mechanisms and Therapeutic Vulnerability

    The authors discuss the contributions of various extracellular matrix components that impact hepatocytes and their surrounding support network during tumorigenesis.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    4 Snyder Institute Researchers Receive Canada Foundation for Innovation Grants for Critical Health Research

    With help from the 2023 Canada Foundation for Innovation John R. Evans Leaders Fund, four outstanding Snyder Institute members are moving their innovative research projects forward and tackling some of the greatest healthcare challenges.
    [University of Calgary]

    Press Release
    FEATURED EVENT

    BioCon Asia 2023 – Advanced Cell & Gene Therapy (ACGT) Conference

    October 12 – 13, 2023
    Singapore & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Clinical Research Nurse- Inflammatory Bowel Disease & Liver Disease

    Vancouver GI and Liver Research and Education Society – Vancouver, British Columbia, Canada

    Professor – Clinical Pediatrics

    University of South California – Los Angeles, California, United States

    Postdoctoral Research Scientist – Cancer Biology

    Columbia University Irving Medical Center – New York City, New York, United States

    Postdoctoral Research Scientist – Cancer Biology

    Columbia University Irving Medical Center – New York City, New York, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    > See All Jobs

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