 | | Vol. 6.17 – 8 September, 2023 |
| |
|
|
| Researchers used various lineage-tracing models and intravital microscopy to visualize, track, and functionally assess monocytes and Kupffer cells in the fibrotic liver environment.
[Science] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors uncovered a mechanism of adenosine monophosphate-activated protein kinase expression in the nonalcoholic fatty liver disease to nonalcoholic steatohepatitis transition, which was mediated by a nuclear mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1)/p38 MAPK-LKB1 axis.
[Nature Communications] |
|
|
|
| Quantitative real-time PCR and immunoblotting were used to detect the expression of ETV4 in HCC tissues and cell lines. RNA sequencing and luciferase reporter assays were performed to identify the target genes of ETV4.
[Cancer Communications] |
|
|
|
| Scientists found that AZGP1 was the key target of lenvatinib in intrahepatic cholangiocarcinoma (ICC), and its low expression in ICC cancer tissues was associated with a poor prognosis in patients.
[Cell Death & Disease] |
|
|
|
| Liver fibrosis was established by carbon tetrachloride administration and compared between liver-specific deletion of FoxO1 deletion and control mice.
[Cellular And Molecular Gastroenterology And Hepatology] |
|
|
|
| Investigators utilized chromone scaffold-based environment-sensitive fluorophores P1 and P2 to detect misfolded and aggregated proteome in stressed liver cells and the liver tissues diseased patients.
[Journal Of Materials Chemistry B] |
|
|
|
| Phase II trials of GC33 to evaluate its efficacy and safety in advanced or metastatic HCC, showed no significant differences in overall survival and progression-free survival compared with the placebo.
[Molecular Immunology] |
|
|
|
| Mutant E3-64 showed increased expression of key genes involved in triterpenoid biosynthesis, as well as different genome-wide single-nucleotide polymorphisms as compared with AC16101.
[Heliyon] |
|
|
|
| Researchers used the human hepatic stellate cell line LX-2 for in vitro assays and used TGF-β1 to induce hepatic fibrosis in LX-2 cells. They analyzed cytotoxicity using a cell-counting kit-8 and transwell chambers to detect the migratory ability of LX-2 cells.
[Digestive Diseases And Sciences] |
|
|
|
|
| The authors provide an overview of studies that analyze the role of cellular stress in different cell types involved in fibrogenesis, including hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells and macrophages.
[Nature Reviews Gastroenterology & Hepatology] |
|
|
|
| Investigators showcase recent studies on the splicing and alternative splicing of key genes in metabolic pathways in the liver, the effect of metabolic signals on the spliceosome, and therapeutic intervention points based on RNA splicing.
[Trends In Endocrinology And Metabolism] |
|
|
|
| Scientists discuss some glucagon-dependent mechanisms by presenting an integrative view on microenvironmental and systemic aspects in pancreatic neuroendocrine tumors and HCC biology.
[Molecular And Cellular Endocrinology] |
|
|
|
|
| The UK government announced that it will rejoin the European Union’s €95 billion research funding program known as Horizon Europe.
[ScienceInsider] |
|
|
|
| The Terry Fox Research Institute is awarding $2.4 million to the Spatial Metabolome Hubble Project. The Spatial Metabolomics Hub is led by Dr. Kyle Duncan, a Vancouver Island University (VIU) Chemistry Professor, and Dr. David Goodlett, Director of the University of Victoria’s Genome BC Proteomics Centre.
[Vancouver Island University] |
|
|
|
|
| October 16 – 19, 2023
Hong Kong |
|
|
|
|
|
| | The Roger Williams Institute of Hepatology – Location |
|
|
|
| | University of California – Los Angeles, California, United States |
|
|
|
| | Vancouver GI and Liver Research and Education Society – Vancouver, British Columbia, Canada |
|
|
|
| | University of South California – Los Angeles, California, United States |
|
|
|
| | Columbia University Irving Medical Center – New York City, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
