 | | Vol. 7.34 – 15 September, 2023 |
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| Researchers generated mice with liver-specific knockout of mineral dust-induced gene (MDIG) and applied partial hepatectomy or carbon tetrachloride mouse models to investigate the biological contribution of MDIG in liver regeneration.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Circular RNA hsa_circ_0001681 was identified by circular RNA sequencing from 19 pairs of intrahepatic cholangiocarcinoma and adjacent tissue samples.
[Journal of Experimental & Clinical Cancer Research] |
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| Due to the high similarity with humans, the authors generated leptin-deficient pigs to investigate the mechanisms and clinical trials of obesity and non-alcoholic fatty liver disease (NAFLD) caused by leptin.
[Cell & Bioscience] |
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| Upon the successful establishment of a battery of cellular models developing resistance to FGFR4 inhibitors, researchers identified the activation of EGFR, MAPK, and AKT signaling as the primary mechanisms mediating the acquired resistance.
[Molecular Cancer Therapeutics] |
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| Through in vivo CRISPR knockout screens targeting related E3 ligase genes in HCC nude mice models, investigators discovered Listerin (LTN1) as a novel tumor suppressor in HCC.
[Hepatology Communications] |
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| Pharmacophore-based virtual screening of a small molecule database was performed initially, and then the screened hits were docked to the active site of SIRT3 to choose the best binding modes.
[Journal Of Biomolecular Structure & Dynamics] |
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| Investigators examined the ameliorative effects of camel milk and silymarin supplementation upon aflatoxin B1 induced hepatic injury in rats.
[Scientific Reports] |
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| Analysis using dot blot and epitranscriptomic chips revealed that the m6A modification pattern of the transcriptome in high-fat diet-induced fatty liver and free fatty acid-induced fatty hepatocytes showed significant changes.
[Nutrition & Metabolism] |
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| Scientists evaluated the anti-proliferative effect of Bacillus coagulans MZY531 and apoptosis induction in the mouse H22 hepatocellular carcinoma cell line.
[BMC Complementary Medicine And Therapies] |
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| The authors discuss the reactive oxygen/nitrogen species (ROS/RNS)-related mechanisms underlying liver fibrosis of distinct etiologies and highlight preclinical and clinical trials of antifibrotic therapies premised on remediating oxidative/nitrosative stress in hepatocytes or targeting hepatic stellate cell activation.
[Trends in Molecular Medicine] |
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| NeuroBo Pharmaceuticals, Inc. announced the dosing of the first patient in its two-part, Phase IIa clinical trial of DA-1241, a novel G-Protein-Coupled Receptor 119 agonist, for the treatment of nonalcoholic steatohepatitis (NASH).
[NeuroBo Pharmaceuticals] |
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| October 20 – 24, 2023
Madrid, Spain |
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| | King’s College London – London, England, United Kingdom |
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| | The Roger Williams Institute of Hepatology – London, England, United Kingdom |
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| | University of California – Los Angeles, California, United States |
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| | Vancouver GI and Liver Research and Education Society – Vancouver, British Columbia, Canada |
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| | University of South California – Los Angeles, California, United States |
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