 | | Vol. 7.35 – 22 September, 2023 |
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| Researchers reported that anti-obesogenic and anti-inflammatory functions of adenosine A2A receptor significantly restrain HCC development. Adora2a deletion in mice triggered obesity, non-alcoholic steatohepatitis (NASH), and systemic inflammation.
[Cell Reports Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that combining an inhibitor of liver ATP citrate lyase (ACLY), bempedoic acid, and the GLP-1R agonist liraglutide reduced liver steatosis, hepatocellular ballooning, and hepatic fibrosis in a mouse model of nonalcoholic steatohepatitis.
[Cell Reports Medicine] |
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| Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[Science Advances] |
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| Investigators found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in intrahepatic cholangiocarcinoma and associated with poorer survival.
[Molecular Therapy] |
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| Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] |
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| Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.
[JHEP Reports] |
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| Investigators reported a fundamental and unexpected role of neutrophils as the predominant phagocyte responsible for the clearance of apoptotic hepatic cells in the steady state.
[eLife] |
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| Researchers showed that phosphoenolpyruvate carboxylase 1 (PCK1) inhibited the self-renewal property of hepatoma cells, reduced the mRNA level of cancer stem cell markers, and inhibited tumorigenesis.
[Genes & Diseases] |
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| The authors uncovered that the potent non-coding RNA Tug1, which was related to metabolic enzymes, regulated hepatocytes steatosis induced by sodium palmitate via miR-1934-3p absorbing.
[Cell Biology And Toxicology] |
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| Immunohistochemistry and western blotting were used to detect the expression level of ADP ribosylation factor 6 (ARF6) in HCC tissues. Investigators analyzed the clinical significance of ARF6 in primary HCC patients.
[Cancer Cell International] |
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| Human hydroxysteroid dehydrogenase-like 2 (HSDL2) expression levels in cholangiocarcinoma cells and tissues were determined by quantitative real-time polymerase chain reaction, western blotting, and immunohistochemistry.
[World Journal of Surgical Oncology] |
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| The authors review the application of ideal histone deacetylase 2 (HDAC2) inhibitors with solid anti-tumor efficacy in combination with immunotherapy for HCC.
[Cancer Cell International] |
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| Researchers at UC Davis Health have infused their first Wilson Disease patient with a gene therapy as part of a groundbreaking new clinical trial. The treatment has the potential to address the underlying cause of the disease.
[UC Davis Health] |
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| October 29 – November 1, 2023
New York, New York, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | The Roger Williams Institute of Hepatology – London, England, United Kingdom |
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| | University of South California – Los Angeles, California, United States |
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| | Columbia University Irving Medical Center – New York City, New York, United States |
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