 | | Vol. 7.36 – 29 September, 2023 |
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| Scientists showed that there was a specific multiplicative interaction between female sex and patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M in determining fatty liver disease in at-risk individuals (steatosis and fibrosis, and advanced fibrosis/HCC) and in the general population.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In this randomized, double-blind, placebo-controlled study, investigators assessed the efficacy and safety of FOLFOX4 with all-trans-retinoic acid as a palliative treatment for HCC patients with extrahepatic metastasis, compared to FOLFOX4 with a placebo.
[Signal Transduction and Targeted Therapy] |
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| Scientists performed a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from HCC cells and found that deletion of scavenger receptor class B member 2 (SCARB2) suppressed the cancer stem cell-like properties of HCC cells.
[Nature Communications] |
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| Researchers conducted a cohort study with data from Swedish university hospitals. Patients with nonalcoholic fatty liver disease (NAFLD) without cirrhosis were diagnosed through biopsy or radiology, and had fibrosis estimated.
[JHEP Reports] |
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| Investigators found up-regulated mitotic arrest deficient 2 (MAD2) facilitated cholangiocarcinoma progression and induced lymphatic metastasis dependent on USP44/LIMA1/PI3K/AKT pathway.
[Oncogene] |
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| The role of nuclear enriched abundant transcript 1 (NEAT1) and kinesin family member 11 (KIF11) in cellular senescence and tumor growth in HCC was assessed both in vitro and in vivo.
[Clinical and Translational Medicine] |
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| The authors investigated the role of caspase recruitment domain family member 9 (CARD9) in the development of nonalcoholic steatohepatitis (NASH). NASH models were established using CARD9-knockout and wild-type mice.
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| The anti-HCC effect of aidi injection was evaluated in various HCC cells and the zebrafish xenograft model.
[Journal of Ethnopharmacology] |
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| Researchers evaluated potential alterations and dynamics of circulating glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in patients undergoing liver resections, focusing on post-hepatectomy liver failure.
[Scientific Reports] |
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| Constitutively hepatocyte-specific histone deacetylase 3 (HDAC3)-deficient mice and constitutively hepatocyte-specific HDAC3 knockout and systemic interleukin-6 simultaneously ablated mice were used to explore the causes of sex differences in HCC.
[BMC Cancer] |
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| The authors focus specifically on the bioactive lipids derived from phospholipids and poly-unsaturated fatty acids in the prevalent chronic hepatopathies.
[Journal of Hepatology] |
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| The Keck School of Medicine of the University of South Carolina (USC) has received funding from the National Institutes of Health as part of a five-year, $50.3 million “multi-omics” study of human health and disease involving six sites.
[University of South Carolina] |
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| November 7 – 8, 2023
London, England, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | University of South California – Los Angeles, California, United States |
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