 | | Vol. 7.37 – 6 October, 2023 |
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| Researchers described single-cell Deep Visual Proteomics, a technology that integrated high-content imaging, laser microdissection, and multiplexed mass spectrometry.
[Nature Methods] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Cysteine-rich angiogenic inducer 61 (CYR61) liver-specific knockout mice on a nonalcoholic steatohepatitis (NASH) diet showed improved glucose tolerance, decreased liver inflammation, and reduced fibrosis.
[Science Translational Medicine] |
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| Scientists identified that soluble folate receptor γ was a secreted protein that was elevated in the livers of patients with metabolic dysfunction–associated steatohepatitis.
[Science Translational Medicine] |
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| The authors elucidated an endocrine pathway that was regulated by skeletal muscle interferon regulatory factor 4 (IRF 4), which manipulated liver pathology.
[Nature Communications] |
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| Researchers identified inhibition of reactive oxygen species levels and reduced redox status in Lenvatinib-resistant HCC. Integrating RNA-seq with unbiased whole-genome CRISPR-Cas9 screen analysis indicated LINC01607 regulated the P62 to enhance drug resistance by affecting mitophagy and antioxidant pathways.
[Cancer Letters] |
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| Scientists investigated a potential role of CRY1/2 in circadian regulation of hepatic cytochromes P450 (CYP) 2A5. Regulatory effects of CRY1/2 on CYP2A5 were determined using cryptochrome 1 (Cry1)-null and Cry2-null mice, and validated using AML-12, Hepa1-6, and HepG2 cells.
[Biochemical Pharmacology] |
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| The authors mapped the phosphorylation rewiring events in palmitic acid (PA)-stimulated HepG2 cells and found PA decreased the phosphorylation level of the eukaryotic translation initiation factor 4E-binding protein 4EBP2 at S65/T70.
[Journal of Biological Chemistry] |
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| The expression of testis expression 10 (Tex10) in the HCC cell line and tissue microarray was determined by Western blot and immunohistochemistry, respectively.
[Molecular Carcinogenesis] |
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| Researchers revealed that growth arrest-specific gene 7 (Gas7) was downregulated in various HCC cell lines and low Gas7 expression was associated with decreased overall survival in patients with HCC.
[Cellular Signalling] |
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| Investigators assessed cell viability, proliferation, invasion, and migration using three cell lines to explore the biological characteristics of receptor-tyrosine-kinase-like orphan receptor-1 antisense 1 (ROR1-AS1) in cholangiocarcinoma.
[BMC Cancer] |
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| Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular heterogeneity in MASH livers providing potentially targetable cell-cell interactions and behavior.
[Science Translational Medicine] |
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| The potential synergy between transarterial radioembolization and immunotherapy has been recognized, and prospective studies evaluating this combination are needed for patients with Barcelona Clinic Liver Cancer B and C HCC.
[Hepatology Communications] |
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| South Korea’s scientists have been left reeling after the government proposed substantial cuts to the 2024 federal research budget. Government spending on research and development in the country has been among the highest in the world and the announcement has sparked a rare outcry from researchers.
[Nature] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | National University of Singapore – Singapore, Singapore |
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| | National University of Singapore – Singapore, Singapore |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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