Hepatic Cell News Volume 7.38 | Oct 13 2023

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    Noshin Noorjahan
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    2023-10-13 | HCN 7.38


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.38 – 13 October, 2023
    TOP STORY

    Spatial-Temporal Proliferation of Hepatocytes during Pregnancy Revealed by Genetic Lineage Tracing

    Researchers employed a proliferation recording system, ProTracer, to examine the spatial-temporal proliferation of hepatocytes during pregnancy.
    [Cell Stem Cell]

    AbstractGraphical Abstract
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    Fibroblast Growth Factor 18 Stimulates the Proliferation of Hepatic Stellate Cells, Thereby Inducing Liver Fibrosis

    The authors demonstrated that the expression of fibroblast growth factor 18 (Fgf18) was elevated in mouse livers following the induction of chronic liver fibrosis models.
    [Nature Communications]

    Full Article

    Tripartite Motif Containing 26 Prevents Steatohepatitis Progression by Suppressing C/EBPδ Signaling Activation

    Scientists showed tripartite motif containing 26 (TRIM26) to be a critical endogenous suppressor of CCAAT/enhancer binding protein delta (C/EBPδ), and confirmed that TRIM26 was an C/EBPδ-interacting partner protein that catalyzed the ubiquitination degradation of C/EBPδ in hepatocytes.
    [Nature Communications]

    Full Article

    Intrinsic Cancer Cell Phosphoinositide 3-Kinase δ Regulates Fibrosis and Vascular Development in Cholangiocarcinoma

    Immunohistochemical analyses of cholangiocarcinoma (CCA) samples revealed a high expression of phosphatidylinositol-3 kinase isoform δ (PI3Kδ) in the less differentiated CCA.
    [Liver International]

    Full Article

    Growth Differentiation Factor 7 Autocrine Signaling Promotes Hepatic Progenitor Cell Expansion in Liver Fibrosis

    Growth differentiation factor 7 (GDF7) expression was analyzed in fibrotic and healthy human liver tissues by immunohistochemistry and qPCR.
    [Stem Cell Research & Therapy]

    Full Article

    Synthetic Augmentation of Bilirubin Metabolism in Human Pluripotent Stem Cell-Derived Liver Organoids

    Researchers used iPSCs to develop human liver organoids that could emulate conjugation failure phenotype. Bilirubin conjugation assays, chromatin immunoprecipitation, and transcriptome analysis elucidated the role of glucocorticoid antagonism in UDP glucuronosyltransferase family 1 member A1 activation.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    AP4M1 as a Prognostic Biomarker Associated with Cell Proliferation, Migration, and Immune Regulation in Hepatocellular Carcinoma

    The expression level of AP4M1 in cancers was investigated by The Cancer Genome Atlas and Gene Expression Omnibus databases, and the correlation between AP4M1 and HCC clinicopathological parameters were analyzed.
    [Cancer Cell International]

    Full Article

    A Model of Hepatic Steatosis with Declined Viability and Function in a Liver-Organ-on-a-Chip

    The authors developed a simple organ-on-a-chip steatosis model using the Mimetas OrganoPlate with a human liver cell line, HepG2.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Recompensation in Cirrhosis: Unravelling the Evolving Natural History of Nonalcoholic Fatty Liver Disease

    Scientists provide an up-to-date perspective on the natural history of nonalcoholic fatty liver disease (NAFLD), emphasizing the reversible nature of the disease, and summarizing possible mechanisms underlying recompensation in NAFLD.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Tumor-Destroying Sound Waves Receive FDA Approval for Liver Treatment in Humans

    The US FDA has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for liver treatment.
    [University of Michigan]

    Press Release
    FEATURED EVENT

    Generation and Application of Organoid Disease Models

    October 29 – November 3, 2023
    Hinxton, England, United Kingdom

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Bioinformatics

    The University of Hong Kong – Hong Kong, Hong Kong

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    Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States

    Research Assistant – Hepatitis Research

    National University of Singapore – Singapore, Singapore

    Research Assistant – Department of Medicine

    National University of Singapore – Singapore, Singapore

    Faculty Positions – Cancer Research

    Houston Methodist Research Institute – Houston, Texas, United States

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