 | | Vol. 7.39 – 20 October, 2023 |
| |
|
|
| MAESTRO-NAFLD-1 was a 52-week randomized, double-blind, placebo-controlled phase III trial evaluating the safety of resmetirom in adults with nonalcoholic fatty liver disease (NAFLD) and presumed nonalcoholic steatohepatitis.
[Nature Medicine] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors comprehensively investigated the transgenerational effects by repeating the original carbon tetrachloride multigenerational study with increased power, pedigree tracing, F2 dose-response, and suitable randomization schemes.
[Nature Communications] |
|
|
|
| Researchers uncovered that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5 interactor (URI) endowed HCC with resistance to tyrosine kinase inhibitor-induced ferroptosis.
[Nature Communications] |
|
|
|
| Scientists examined the spectrum of acquired resistance mechanisms detected in circulating tumor DNA or tumor tissue upon disease progression following FGFR inhibitor therapy in 82 FGFR-altered cholangiocarcinoma patients from 12 published reports.
[Clinical Cancer Research] |
|
|
|
| Investigators observed that hepatocyte-specific overexpression of ubiquitin-specific protease 39 (USP39) promoted hepatocarcinogenesis and potently regulated splice site selection in transgenic mice. In human liver cancer cells, USP39 promoted tumor proliferation in a spliceosome-dependent manner.
[Cell Death & Disease] |
|
|
|
| The authors manifested that Sorcin was considerably upregulated, whereas pyroptosis-associated proteins were significantly decreased in HCC tissues and cells.
[Cell Death & Disease] |
|
|
|
| Scientists investigated the mechanisms of occurrence and development of acute liver injury (ALI) in lipopolysaccharide-induced ALI mice.
[Acta Pharmacologica Sinica] |
|
|
|
| Researchers investigated the function of long noncoding RNA small nucleolar RNA host gene 9 (SNHG9) in liver cancer stem cell self-renewal and tumorigenesis.
[Cell And Tissue Research] |
|
|
|
| Investigators identified a critical role of gallic acid (GA) in inducing ferroptosis in HepG2 cells. They confirmed that GA is a novel ferroptosis inducer of HCC.
[Naunyn-Schmiedebergs Archives Of Pharmacology] |
|
|
|
|
|
| Scientists review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment.
[Molecular Medicine] |
|
|
|
| The authors summarize the pharmacokinetic characteristics of the antigiogenic drugs currently approved for the treatment of HCC, from oral tyrosine kinase inhibitors to monoclonal antibodies.
[Expert Opinion on Drug Metabolism & Toxicology] |
|
|
|
|
| Metabolon, Inc., announced the launch of its new Liver Fibrosis and Kidney Function Discovery Panels.
[Metabolon Inc.] |
|
|
|
| Scientists in Argentina are on edge as the country’s presidential election approaches. If elected president, economist Javier Milei has pledged to eliminate government spending on research and shut down the environment and health ministries.
[Nature] |
|
|
|
|
| November 15 – 17, 2023
Seoul, Korea |
|
|
|
|
|
| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
|
|
|
| | The University of Hong Kong – Hong Kong, Hong Kong |
|
|
|
| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
|
|
|
| | National University of Singapore – Singapore, Singapore |
|
|
|
| | National University of Singapore – Singapore, Singapore |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
