 | | Vol. 7.40 – 27 October, 2023 |
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| Using a STelic Animal Model, investigators treated male mice, which developed diabetes, nonalcoholic steatohepatitis, and HCC associated with dysbiosis upon low-dose streptozotocin and high-fat diet, with insulin or phlorizin.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A phenotype-based high-content screening was performed and RING finger protein 13 (RNF13) was identified as an effective inhibitor of lipid accumulation in vitro.
[Nature Communications] |
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| Scientists conducted a CRISPR/Cas9 library screening targeting epigenetic factors and identified coactivator-associated arginine methyltransferase 1 (CARM1) as a critical inhibitor of ferroptosis.
[Molecular Therapy – Nucleic Acids] |
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| The authors explored the role of nuclear respiratory factor 1 in HCC progression and investigated the underlying mechanisms.
[Biology Direct] |
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| Zinc finger protein 281 (ZNF281) knockdown increased the expression of mitochondrial transcription factor A in HCC cells, accompanied by an increment of mitochondrial content, oxygen consumption rate, and levels of tricarboxylic acid cycle intermetabolites.
[Cell Death Discovery] |
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| Investigators engineered a novel GPC3-targeting CAR including an anti-GPC3 scFv, CD3ζ, CD28, and 4-1BB that induced co-expression of IL-7 at a moderate level and CCL19 at a high level, and transduced it into human T cells.
[Cell Biology and Toxicology] |
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| KH domain-containing, RNA-binding signal transduction-associated protein 3 (KHDRBS3) knockdown and overexpression were performed using the lentiviral vector system to investigate the effects of KHDRBS3 on cell proliferation, apoptosis, chemoresistance, and glycolysis.
[Cancer Cell International] |
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| Researchers used a comprehensive approach to investigate the effects of ABHD12, which regulated tumorigenesis and sorafenib resistance in liver hepatocellular carcinoma.
[iScience] |
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| Hypoxic HCC cell-derived exosomes (H-LM3-exos) were used to induce hepatocytes over the long term. A nude mouse experiment further verified the effect of H-LM3-exos on tumor growth and metastasis.
[Molecular Pharmaceutics] |
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| The authors consider the role of impaired mitochondrial function caused by lipotoxicity during oxidative stress in hepatocytes.
[Journal of Translational Medicine] |
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| Scientists provide an overview of up-regulated circular RNAs that mediate efficacy in preclinical in vivo models of HCC.
[Cancer Genomics & Proteomics] |
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| Keep working on it. That’s the reaction of US science watchdog groups to the first attempts by federal health agencies to flesh out a promise by President Joe Biden to restore trust in government by ensuring that government scientists are free to do their jobs without political meddling.
[ScienceInsider] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | The University of Hong Kong – Hong Kong, Hong Kong |
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| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
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| | National University of Singapore – Singapore, Singapore |
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