 | | Vol. 7.41 – 3 November, 2023 |
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| Researchers showed that optic atrophy 1 (OPA1) was required for proper complex V assembly and that OPA1 liver knockout protected the liver from drug toxicity.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists employed a lysine-targeted sulfonyl fluoride probe, named XO44, which bound to 133 endogenous kinases in intact lenvatinib-resistant HCC cells.
[Nature Communications] |
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| Four human HCC cohorts and four mouse HCC models were assessed for expression and localization of nuclear factor kappa B signaling components and activating ligands.
[Hepatology] |
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| Investigators found that cFAM210A could be silenced by hepatitis B protein x (HBx). cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with hepatitis B virus-related HCC.
[Experimental & Molecular Medicine] |
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| The authors used a choline-deficient high-fat diet-induced murine model and investigated the effect of L. plantarum on nonalcoholic steatohepatitis (NASH) pathogenesis using transcriptomic, metagenomic, and immunohistochemistry analyses.
[Experimental & Molecular Medicine] |
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| Investigators found that Beta1,4-galactosyltransferase (B4GALT) 1 was significantly downregulated in HCC tissue compared with the adjacent liver tissue, and low B4GALT1 expression was associated with vascular invasion and poor overall survival in patients with HCC.
[Oncogenesis] |
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| Investigators reported that high-fat diet feeding induced hepatic steatosis in mice, which was accompanied by a reduction in the expression and function of hepatic TRPV2.
[Journal Of Physiology And Biochemistry] |
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| Using the zebrafish model of liver progenitor cell (LPC)-mediated liver regeneration, scientists presented that peroxisome proliferator-activated receptor-alpha (PPARα) activation augmented LPC-to-hepatocyte differentiation.
[Scientific Reports] |
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| The authors investigated the regulatory and transcriptional landscape in fatty livers and liver tumors from DIAMOND mice that faithfully mimicked human HCC development in the context of metabolic associated fatty liver disease.
[Scientific Reports] |
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| Investigators review the safety and efficacy of anticoagulation in advanced liver disease and consider whether antithrombotic agents could slow or halt the progression of fibrosis in metabolic-associated fatty liver disease.
[Journal of Thrombosis and Haemostasis] |
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| To better understand the mechanisms behind the decline of liver regeneration in the elderly, researchers from the University of California, San Francisco will send tissue chips containing liver cells and immune cells to space.
[ISS National Lab] |
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| November 15 – 17, 2023
Seoul, Korea |
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| | University of Western Australia – Perth, Australia |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | The University of Hong Kong – Hong Kong, Hong Kong |
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| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
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