 | | Vol. 7.42 – 10 November, 2023 |
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| The authors revealed E3 ligase FBXW7 as a key factor regulating hepatic catabolism, stress responses, systemic energy homeostasis, and nonalcoholic steatohepatitis (NASH) pathogenesis with attenuated FBXW7 expression as a feature of advanced NASH.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated an edited c.1222C>T hepatocyte cell line and humanized c.1222C>T mouse models, with which scientists demonstrated efficient in vitro and in vivo correction of the variant with prime editing.
[American Journal Of Human Genetics] |
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| The transcription of lncRNA-Gm9866 in activated cells and mouse fibrotic livers was determined by qPCR. The effects of lentivirus-mediated knockdown or overexpression of lncRNA-Gm9866 in liver fibrosis were examined in vitro and in vivo.
[Journal Of Translational Medicine] |
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| Investigators showed 3D organoids generated from liver stem cells from actively Hepatitis C virus-infected individuals carried replicating virus and maintained low-grade infection over months.
[mBio] |
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| Scientists utilized zebrafish to create the liver fibrosis model and investigate the therapeutic mechanism of naringin. They evaluated the changes in hepatic fibrosis and lipid accumulation in the liver following naringin treatment with oil red O, Nile red, and Sirius red and immunohistochemistry.
[Food & Function] |
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| Researchers showed that pioglitazone administration increased the amount of linoleic acid metabolites in adipose tissue of KK-Ay mice.
[Scientific Reports] |
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| Primary hepatocytes were isolated from black seabream juveniles and treated with oleic acid (OA), OA + transfection with non-silencing control siRNA, and OA + transfection with ire1α-small interfering RNA for 48 hours versus untreated.
[Fish & Shellfish Immunology] |
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| Liver-targeting ligand glycyrrhetinic acid was conjugated to polyethylene glycol via Steglich reaction and incorporated in liposomes, which were then loaded with doxorubicin hydrochloride by pH gradient method.
[Pharmaceutical Development and Technology] |
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| To evaluate the role of ski-related novel gene in hepatic fibrosis (HF), investigators combined bulk RNA sequencing analysis and single-cell RNA sequencing analysis to analyze patients with HF.
[Biomolecules & Biomedicine] |
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| The authors describe the epidemiology of inflammatory bowel disease in primary sclerosing cholangitis, its specific phenotype, complications and potential pathophysiological mechanisms connecting the two diseases.
[Journal Of Hepatology] |
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| Now in its second year, the Yale Conference for Alcohol Research and Education was held on September 30, 2023. Offering a comprehensive agenda of talks, panel discussions, and poster presentations, the all-day event brought together Yale’s researchers and clinicians under the banner of alcohol research.
[Yale School of Medicine] |
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| Last month, Cirius Therapeutics of Kalamazoo, Michigan, shipped nearly 8,000 samples from 642 liver patients to VCU’s Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, which Dr. Sanyal leads.
[VCU Health] |
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| December 16 – 20, 2023
Waikoloa Beach, Hawaii, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | University of Western Australia – Perth, Australia |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | The University of Hong Kong – Hong Kong, Hong Kong |
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