 | | Vol. 7.47 – 15 December, 2023 |
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| Investigators found that macrophage-derived itaconate promotes HCC by epigenetic induction of Eomesodermin-mediated CD8+ T cell exhaustion.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Induced pluripotent stem-cell-derived hepatocytes engineered to contain FLAG-tagged, doxycycline-inducible IFNLR1 isoform constructs were HBV-infected and then treated with IFNL3 followed by assessment of gene expression, HBV replication, and cellular viability.
[Antiviral Research] |
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| Scientists acquired scRNA-seq datasets about HCC, which enabled them to identify distinct cell subpopulations within HCC tissues. They conducted a differential analysis to pinpoint DEGs associated with normal fibroblasts and cancer-associated fibroblasts.
[NPJ Precision Oncology] |
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| Hepatocyte-specific gp78 knockout or overexpressed mice were generated to examine the effect of gp78 on liver ischemia-reperfusion injury, and a multi-omics approach was performed to explore the potential mechanism.
[Cell Death & Disease] |
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| Scientists investigated the potential therapeutic role of chemokine receptors in the migration of natural killer cells in a murine hepatitis virus strain 3-induced fulminant hepatic failure model and its mechanism.
[Journal Of Translational Medicine] |
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| Researchers analyzed SPRTN and UPR in 21 human HCC tissue samples using RT-qPCR, immunoblot, and immunohistochemistry. They found alterations in the expression levels of SPRTN and UPR-related genes and proteins in HCC samples.
[Cancer Gene Therapy] |
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| Investigators explored the role of brain and muscle aryl hydrocarbon receptor nuclear translocator-like1 (BMAL1), a circadian clock regulator, in the development of obesity and non-alcoholic fatty liver disease.
[International Journal Of Obesity] |
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| 3D biohybrid constructs were created by combining hepatocyte-like cells derived from patient-specific footprint-free human induced pluripotent stem cells and 3D melt-electrospun poly-ε-caprolactone scaffolds.
[Scientific Reports] |
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| Transcriptional profile analysis was used to analyze expression of circRNAs in HCC in this study. The top ten upregulated circRNAs were selected and validated by quantitative reverse transcription polymerase chain reaction in another 34 HCC patients.
[Scientific Reports] |
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| The authors summarize the characteristics of various hepatic fibrosis and programmed cell death, focus on the latest progress of programmed cell death in the promotion and regression of hepatic fibrosis, and highlight the different roles of the programmed cell death of hepatic stellate cells and other liver cells.
[Cell Death Discovery] |
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| 89bio, Inc. announced a successful end-of-phase II Meeting with the US FDA, supporting the advancement of pegozafermin into Phase III in NASH.
[89bio, Inc.] |
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| January 20 – 24, 2024
Seefeld, Austria |
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| | National University of Singapore – Singapore, Singapore |
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| | Virginia Tech – Blacksburg, Virginia, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | University of California San Francisco – San Francisco, California, United States |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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