 | | Vol. 7.46 – 8 December, 2023 |
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| Investigators found the C-type lectins including Colec10 and Colec11 were not produced by hepatocytes but predominantly produced by hepatic stellate cells, especially quiescent ones in the mice livers.
[Cell Death & Disease] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists elucidated the role of DDX5 in sensitizing HCC to sorafenib, offering new therapeutic strategies.
[Cell Death & Disease] |
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| Researchers investigated the consequences of S-palmitoylation of signal transducer and activator of transcription 3 (STAT3) in HCC. In HepG2 cells in vitro, DHHC7-mediated palmitoylation enhanced the expression of STAT3 target genes, including HIF1A.
[Science Signaling] |
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| Investigators observed a significant upregulation of RPLP2 in HCC tissues. Moreover, RPLP2 expression was closely correlated with patient prognosis and survival.
[Cell Death Discovery] |
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| Researchers showed in mice that hepatocyte proliferation was spatiotemporally regulated in each liver lobular zone during pregnancy, with transient proliferation of periportal and pericentral hepatocytes during mid and late gestation, respectively.
[Communications Biology] |
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| Investigators found that the levels of invadopodia-associated proteins were significantly higher in liver metastasis than in the primary tumors of patients with gastric cancer with liver metastasis.
[Cancer Science] |
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| Scientists explored whether an increase in hepatocyte-derived high-mobility group box-1 (HMBG1) in a mouse model of inactivation of PTEN that causes metabolic dysfunction-associated steatohepatitis (MASH) could promote MASH-induced tumorigenesis.
[Hepatology Communications] |
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| The authors investigated the effects of β-sitosterol on HCC tumor growth and metastasis using a xenograft mouse model and a range of molecular analyses, including bioinformatics, real-time PCR, western blotting, lentivirus transfection, CCK8, scratch and transwell assays.
[Journal Of Cellular And Molecular Medicine] |
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| Researchers clarified whether aspirin exerted its anti-HCC effect by inhibiting PD-L1 expression. The rat model of HCC was established by drinking 0.01% diethylnitrosamine, and aspirin was given by gavage.
[Scientific Reports] |
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| The authors summarize recent findings reported in preclinical and clinical studies on mechanisms of liver cell death, alongside the participation of IL1 family members consisting of IL1α, ILβ, IL18, and IL33 in liver cell death and their significant implications in liver diseases.
[Expert Opinion On Therapeutic Targets] |
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| Korro Bio, Inc. has nominated its first development candidate, KRRO-110, for the potential treatment of AATD. KRRO-110 is a proprietary RNA editing oligonucleotide delivered to liver cells using clinically validated LNP technology licensed from Genevant.
[Korro Bio, Inc.] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | Virginia Tech – Blacksburg, Virginia, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | University of California San Francisco – San Francisco, California, United States |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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| | Animal & Plant Health Agency – Addlestone, England, United Kingdom |
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