 | | Vol. 8.03 – 26 January, 2024 |
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| Investigators unraveled that the expression of the transcription factor Zbtb18 was markedly decreased in the livers of both patients and murine models of non-alcoholic fatty liver disease (NAFLD).
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists characterized a proinflammatory fibroblast population, which corresponded to an early state of myofibroblast differentiation in chronic kidney disease.
[Nature Communications] |
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| Scientists discovered that trimethylated histone H3 lysine 4 and H3 lysine 27 acetylation modification in the promoter region of YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) enhanced its expression in HCC, and upregulated YTHDF2 in HCC predicted a worse prognosis.
[Advanced Science] |
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| Scientists implicated neutrophil extracellular traps (NETs) playing a critical role in the development of metabolic dysfunction-associated steatohepatitis (MASH)-hepatic fibrosis by inducing metabolic reprogramming of hepatic stellate cells via the TLR3/COX-2/PGE2 pathway.
[Hepatology] |
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| Researchers evaluated the clinical significance of YTHDF1 using human HCC samples and found that YTHDF1 was significantly upregulated in HCCs with high stemness scores and was positively associated with recurrence and poor prognosis.
[Cancer Research] |
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| Old donor liver ECM induced lower marker expression in early differentiation stages, compared to young liver ECM, while this difference was closed at later stages and did not affect induced pluripotent stem cell (iPCS)-hepatocyte function significantly.
[Advanced Healthcare Materials] |
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| Researchers elucidated the possible significance of Yes-associated protein (YAP) inhibition in biliary fibrosis by examining the pathophysiology of hepatic stellate cells and biliary epithelial cells
[Aging And Disease] |
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| Investigators demonstrated a vital role for cVIM in promoting liver fibrosis progression and provide a fresh perspective on circRNAs in liver fibrosis.
[Communications Biology] |
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| Researchers explored the tumor ecosystem in HCC to help gain a deeper understanding and design more effective immunotherapy strategies for patients with HCC with or without hepatitis B virus infection.
[Hepatology Communications] |
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| Scientists summarized changes in liver sinusoidal endothelial cells (LSECs) during liver fibrosis and their interactions with hepatic milieu, as well as possible therapeutic approaches that specifically target LSECs.
[Molecular Medicine Reports] |
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| Early studies have shown that Ozempic and other similar drugs may reduce liver damage. Researchers at Karolinska Institutet conducted a register-based study including all people in Sweden with chronic liver disease and Type 2 diabetes.
[Study Finds] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | National University of Singapore – Singapore, Singapore |
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| | Instituto de Investiga̤̣o e Inova̤̣o em Sa̼de da Universidade do Porto РPorto, Portugal |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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