 | | Vol. 8.04 – 2 February, 2024 |
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| Scientists found that, in HCC patients and animal models, advanced glycation end-products promoted changes in collagen architecture and enhanced extracellular matrix viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a strategy that combined CD44-targeting of activated hepatic stellate cells (HSCs) with an antioxidative approach. They demonstrated that intravenously administered hyaluronic acid–bilirubin nanoparticles effectively targeted the liver in fibrotic mice.
[ACS Nano] |
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| Investigators comprehensively identified genes essential for survival of MYChigh but not MYClow cells by a CRISPR/Cas9 genome-wide screen in a MYC-conditional HCC model.
[Nature Communications] |
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| Researchers revealed that UPF1 regulated the abundance of hepatocellular carcinoma and upregulated EZH2-associated lncRNA (lncRNA-HEIH) by binding the CG-rich motif, thereby regulating HCC tumorigenesis.
[Experimental & Molecular Medicine] |
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| The authors developed a silica cross-linked micelles (SCLMs) based nano-system for both diagnosing and treating liver fibrosis. The SCLMs were firstly modified with peptide CTCE9908 and could actively target CXCR4, which was overexpressed in activated hepatic stellate cells.
[Advanced Healthcare Materials] |
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| Scientists found that pancreatic ductal adenocarcinoma cells could promote the formation of pre-metastatic niches through exosomes to facilitate liver metastasis in the early stage. Hepatic stellate cells were treated with PDAC-derived exosomes, and the activation of HSCs was detected.
[Cell Death & Disease] |
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| Researchers explored the function and mechanism of Robo2 and its downstream target genes in HCC. Robo2 protein levels in human HCC tissues and paired adjacent normal liver tissues were detected.
[Scientific Reports] |
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| Investigators conducted a comprehensive investigation into the role of G6PD in liver hepatocellular carcinoma using a combination of bioinformatics analysis with database data and rigorous cell experiments.
[BMC Cancer] |
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| The authors explore the mechanisms of action of oleanolic acid (OA) compounds in both in vitro and in vivo research models and, ultimately, highlight OA as a promising candidate for alternative therapies in the treatment and management of chronic liver disease.
[Naunyn-Schmiedebergs Archives Of Pharmacology] |
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| A new study of aging US veterans finds that one in every 10 who have been diagnosed with dementia might have brain impairments caused by liver cirrhosis. “It’s a condition called hepatic encephalopathy, and it’s often treatable”, explained Dr. Jasmohan Bajaj, of the the Richmond VA Medical Center in Virginia.
[United Press International] |
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| February 22 – 24, 2024
Rotterdam, Netherlands |
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| | University of Antwerp – Antwerp, Belgium |
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| | National University of Singapore – Singapore, Singapore |
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| | National University of Singapore – Singapore, Singapore |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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