Hepatic Cell News Volume 8.05 | Feb 9 2024

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    2024-02-09 | HCN 8.05


    Hepatic Cell News by STEMCELL Technologies
    Vol. 8.05 – 9 February, 2024
    TOP STORY

    HIV Coinfection Exacerbates HBV-Induced Liver Fibrogenesis through a HIF-1α- and TGF-β1-Dependent Pathway

    Investigators found that HIV and HIV gp120 activated AKT and ERK signaling and subsequently upregulated hypoxia-inducible factor-1α (HIF-1α) to increase HBV-induced transforming growth factor beta 1 (TGF-β1) and profibrogenic gene expression in hepatocytes and hepatic stellate cells.
    [Journal Of Hepatology]

    Full ArticleGraphical Abstract
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    DNA Hypomethylation Activates Cdk4/6 and Atr to Induce DNA Replication and Cell Cycle Arrest to Constrain Liver Outgrowth in Zebrafish

    Researchers uncovered decreased Cdkn2a/b and persistent Cdk4/6 activation as the mechanism driving uhrf1 mutant hepatocytes into S-phase. This induced replication stress, DNA damage and Atr activation.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract

    PARD3 Drives Tumorigenesis through Activating Sonic Hedgehog Signaling in Tumor-Initiating Cells in Liver Cancer

    The essential role of Par-3 Family Cell Polarity Regulator (PARD3) in mediating hepatic tumorigenesis was assessed in diet-induced spontaneous liver tumour and syngeneic tumour models. The mechanism of PARD3 was delineated by bulk and single-cell RNA sequencing.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    CircDCBLD2 Alleviates Liver Fibrosis by Regulating Ferroptosis via Facilitating STUB1-Mediated PARK7 Ubiquitination Degradation

    qRT-PCR, Western blot, and immunohistochemistry assays were used to detect the related molecule levels. HE, Masson’s trichrome, and Sirius Red staining were used to assess the pathological changes in mice’s liver tissues.
    [American Journal Of Gastroenterology]

    Abstract

    GITRL Impairs Hepatocyte Repopulation by Liver Progenitor Cells to Aggravate Inflammation and Fibrosis by GITR+CD8+ T Lymphocytes in CDE Mice

    Scientists found that the proportion of liver progenitor cells double positive for the ligand of glucocorticoid-induced tumor necrosis factor receptor and SRY-related HMG box transcription 9 among nonparenchymal cells increased time-dependently upon diet supplemented with ethionine injury and reduced after recovery.
    [Cell Death & Disease]

    Full Article

    Arbidol Attenuates Liver Fibrosis and Activation of Hepatic Stellate Cells by Blocking TGF-β1 Signaling

    Oral administration of Arbidol significantly ameliorated bile duct ligated-induced liver injury/fibrosis as reflected by decreased serum levels of alanine aminotransferase, aspartate aminotransferase, reduced collagen deposition, and diminished mRNA expression of fibrosis markers.
    [European Journal Of Pharmacology]

    Full ArticleGraphical Abstract

    Therapeutic Potential and Mechanisms of Rifaximin in Ameliorating Iron Overload-Induced Ferroptosis and Liver Fibrosis In Vivo and In Vitro

    In an iron overload-induced liver fibrosis model in mice and in ferric ammonium citrate-stimulated primary hepatocytes, treatment with rifaximin showed significant therapeutic effects.
    [Toxicology And Applied Pharmacology]

    Abstract

    Use of Antioxidant Nanoliposomes for Co-Delivery of PTEN Plasmids and Plumbagin to Induce Apoptosis in Hepatic Cancer Cells

    Researchers engineered nanoliposomes containing phosphatase and tensin homolog deleted on chromosome ten (PTEN) plasmids, plumbagin, and antioxidant cerium oxide nanoparticles to restore the PTEN expression and inhibit the AKT/PI3K pathway.
    [Biomedical Materials]

    Abstract

    3D Bioprinted Liver-on-a-Chip for Drug Cytotoxicity Screening

    Investigators employed 3D printing techniques to automate the fabrication process of tissue spheroids on a chip. This allowed the simultaneous high-throughput printing of human liver spheroids and their surrounding polymeric flow chamber “chips” containing inner channels in a single step.
    [Tissue Engineering Part A]

    Full Article
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    REVIEWS

    Liver Fibrosis: Pathological Features, Clinical Treatment and Application of Therapeutic Nanoagents

    The pathological features of liver fibrosis and the current anti-fibrosis drugs in clinical trials are briefly introduced, followed by a detailed introduction of the therapeutic nanoagents for the precise delivery of anti-fibrosis drugs.
    [Journal Of Materials Chemistry B]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BST02 Receives FDA Fast Track Designation in Liver Cancer Management

    The FDA has granted fast track designation to the investigational T cell therapy BST02 as a treatment for patients with liver cancer, according to a press release from Biosyngen.
    [Cancer Network]

    Press Release

    Eli Lilly Says Weight Loss Drug Shows Promise as Treatment for Fatty Liver Disease

    Eli Lilly on February 6, 2024 said its highly popular drug used for weight loss and diabetes showed promise as a treatment for fatty liver disease in a midstage trial.
    [CNBC]

    Full Article
    FEATURED EVENT

    2024 Fibroblast Growth Factors in Development and Disease Conference GRC

    March 24 – 29, 2024
    Galveston, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Senior Research Assistant – Epigenetics & Molecular Carcinogenesis

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Research Fellow – T Cell Retention in the Liver

    University College London – London, England, United Kingdom

    PhD Fellow – Viral Hepatitis and Disease Modelling

    University of Antwerp – Antwerp, Belgium

    Research Fellow – Achieving Functional Cure of Chronic Hepatitis B

    National University of Singapore – Singapore, Singapore

    Research Fellow – iPSCs and/or Hepatobiology

    National University of Singapore – Singapore, Singapore

    > See All Jobs

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