 | | Vol. 8.06 – 16 February, 2024 |
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| Scientists explored the impact of protein corona on extracellular vesicles (EVs) derived from two culturing conditions in which specific proteins acquired from media were simultaneously adsorbed on the EV surface.
[Nature Nanotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1 promoted SARS-CoV-2 pseudovirus infection of HeLa cells.
[Signal Transduction And Targeted Therapy] |
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| Hepatocyte-specific SRY knock-in, SRY knockout, and SRY KI with platelet-derived growth factor receptor α KO mice were generated. Liver fibrosis was induced in mice by bile duct ligation for two weeks or carbon tetrachloride treatment for six weeks.
[Journal Of Hepatology] |
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| The authors found that HSP90β was a key sonic hedgehog (SHH) downstream molecule for promoting NASH process. In hepatocytes, SHH reduces HSP90β ubiquitylation through deubiquitylase USP31, thus preventing HSP90β degradation and promoting hepatic lipid synthesis.
[Nature Communications] |
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| TAp63 was induced in hepatic stellate cells from animal models and patients with liver fibrosis and its levels positively correlated with nonalcoholic fatty liver disease activity score and fibrosis stage.
[Cell Reports Medicine] |
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| Both in vitro and in vivo assays were employed to examine the impact of early growth response 1 (EGR1) on the growth of HCC. The mouse HCC model and human organoid assay were utilized to assess the potential of EGR1 as a gene therapy for HCC.
[Journal Of Experimental & Clinical Cancer Research] |
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| Gene expression and genome-wide chromatin accessibility profiling reveal that nuclear LINC00313 transcriptionally regulated genes involved in Wnt signaling, such as the transcriptional activator TCF7.
[EMBO Reports] |
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| Investigators characterized the pro-fibrogenic function of small nucleolar host gene 11 (SNHG11). Their data showed that in carbon tetrachloride treated C57BL/6J mice, SNHG11 expression was highly up-regulated in fibrotic livers and activated primary hepatic stellate cells.
[Biochemical Pharmacology] |
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| Scientists performed spatial transcriptomics and single nucleus RNA sequencing on matched specimens from patients with either histologically normal or advanced fibrosis to establish important aspects of tissue handling, data processing, and downstream analyses of biobanked liver samples.
[Scientific Reports] |
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| Investigators delve into metabolic dysfunction-associated steatotic liver disease-HCC associated genetic variations and somatic mutations, disease progression and research models, multi-omics analysis, immunological and microenvironmental impacts.
[Hepatology] |
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| Dr. Taran Gujral and his lab created a drug-matching platform that uses artificial intelligence to help researchers, clinicians and, most importantly, patients find additional uses for drugs that have already gone through clinical trials and received approval from the US FDA.
[Fred Hutch Cancer Center] |
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| Canadian researchers led by Montreal radiologist Gilles Soulez have developed a novel approach to treat liver tumors using magnet-guided microrobots in an MRI device.
[University of Montreal Hospital (EurekAlert!)] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | King’s College Hospital – London, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University College London – London, England, United Kingdom |
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| | University of Antwerp – Antwerp, Belgium |
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| | National University of Singapore – Singapore, Singapore |
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