 | | Vol. 8.07 – 23 February, 2024 |
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| In this Phase III, 12-month, double-blind, placebo-controlled trial, researchers randomly assigned patients who had had an inadequate response to or who had a history of unacceptable side effects with ursodeoxycholic acid to receive oral seladelpar at a dose of 10mg daily or placebo.
[New England Journal Of Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Short- and long-term ASK1 inhibition using small molecule GS-444217 was tested in thioacetamide-induced and BALB/c.Mdr2-/- murine models of cirrhosis and HCC, and in vitro using primary hepatocyte cell death assays.
[Hepatology] |
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| By mass spectrometry and bioinformatics analysis, investigators identified SAV1 as a novel substrate of PTS in HCC. Oxidative stress upregulates the transcription of SLC35B2, a Golgi-resident transporter of sulfate donor 3’-phosphoadenosine 5’-phosphosulfate, leading to increased sulfation of SAV1.
[Hepatology] |
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| Researchers observed a decrease in the expression of KIF18A in fibrotic liver tissues compared to healthy liver tissues, which exhibited a negative correlation with the activation of hepatic stellate cells.
[Cellular And Molecular Life Sciences] |
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| The authors induced an acute inflammatory regenerative niche on the surface of the liver by the application of cryo-injury to systematically evaluate the innate immune response against transplanted allogeneic hepatic progenitors in a sustained micro-inflammatory environment.
[Stem Cell Research & Therapy] |
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| In male C57BL/6 mice, chronic variable stress reduced energy expenditure (EE) and body mass despite increased energy intake versus controls. This coincided with decreased glucose metabolism and increased lipid ß-oxidation, correlating with EE.
[iScience] |
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| Cryptogenic non-cirrhotic HCC exhibited similarities with non-cirrhotic NAFLD HCC, but displayed advanced tumor stages, lower surgical rates, and a more frequent presence of symptoms, which substantiated in poor survival rates.
[Scientific Reports] |
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| Scientists investigated the involvement of hydroxymethylase ten–eleven translocation 1 (TET1) in HSC activation and liver fibrosis. It was revealed that TET1 levels were downregulated in the livers in mouse models of liver fibrosis and patients with cirrhosis.
[Journal Of Gastroenterology And Hepatology] |
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| Wild female and male rats were administrated orally with warfarin for 18 days at 9, 18, 27.5, and 55 mg/kg, respectively. Hepatoxicity was determined by assessing, LD50, leukocyte counts, immunochemistry, histopathology, serum proteins, Western blotting, especially of markers of liver injury.
[Heliyon] |
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| Scientists highlight on the bright side of Fusarium oxysporum and introduce the functional activities of its chemical compounds for treating its target diseases.
[Heliyon] |
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| NorthSea Therapeutics B.V. announced the dosing of the first patient in its Phase IIa clinical trial of Orziloben in IFALD, an orphan liver disease affecting individuals on prolonged intravenous nutrition.
[NorthSea Therapeutics B.V.] |
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| Arjamand Mushtaq, a research scholar from the Centre for Interdisciplinary Research and Innovations, Kashmir University has been awarded the prestigious Chandrasekhar Memorial Award, 2024 for her contributions to Biomedical Sciences.
[Brighter Kashmir] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | Leeds Teaching Hospital – Leeds, England, United Kingdomn |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | King’s College Hospital – London, England, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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