 | | Vol. 8.09 – 5 April, 2024 |
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| The authors carried out genomic sequencing in a uniquely affected family with an index case of liver failure and 2 homozygous siblings with minimal or no liver disease.
[Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified lncRNA TILAM located near COL1A1, expressed in HSCs, and induced with liver fibrosis in humans and mice. Loss-of-function studies in human HSCs and human liver organoids revealed that TILAM regulates expression of COL1A1 and other ECM genes.
[Hepatology] |
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| Investigators elucidated the underlying mechanisms of acetyl-CoA synthetase 2 (ACSS2) in liver cancer and acetate metabolism, the relationships between patient acetate uptake and metabolic characteristics and between ACSS2 and tumor malignancies were comprehensively studied in vitro, in vivo and in humans.
[Experimental & Molecular Medicine] |
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| ADAR2+/+/GluR-BR/R mice and ADAR2−/−/GluR-BR/R mice were subjected to feeding with standard chow or high-fat diet for 20 weeks at the age of 5 weeks.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Researchers showed that Hu antigen R was SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease.
[Cell Reports] |
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| The authors showed that regulated adipose tissue (AT) regeneration in doxycycline-fed Tg-AT-hAGPAT2;mAgpat2-/- mice partially ameliorated hepatic steatosis at 12 weeks of age and caused reduced expression of genes involved in hepatic de novo lipogenesis despite partial AT regeneration compared to that in wild-type mice.
[iScience] |
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| Investigators acquired transcriptomic data, corresponding clinical data, and tumor mutation data of HCC from the TCGA database. Disulfidptosis-related (DRLs) lncRNAs were determined through correlation analysis.
[Scientific Reports] |
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| The scientists explored the in vivo dynamics of hepatic extracellular ATP and Ado during the progression of steatohepatitis using a genetically encoded GPCR-activation-based sensor in zebrafish models.
[Scientific Reports] |
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| Researchers investigated the effect of acacetin on hepatic stellate cell apoptosis, thereby improving hepatic fibrosis, and combined experimental validation and molecular docking to reveal the underlying mechanism.
[Heliyon] |
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| Investigators exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for parenteral nutriion associated liver disease. Liver organoids mimic the developing liver and contain the different hepatic cell types.
[Journal Of Pediatric Gastroenterology And Nutrition] |
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| The authors summarize the reported drivers of T cell exhaustion in hepatocellular carcinoma and delineate potential ways to reverse it.
[Pharmacological Research] |
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| A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional, ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.
[Nature News] |
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| | Cleveland Clinic – Cleveland, Ohio, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | Foundation for Liver Research – London, England, United Kingdom |
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