 | | Vol. 8.10 – 12 April, 2024 |
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| The authors investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis. HSC-specific or myofibroblast-specifiSuv39h1 deletion was achieved by crossbreeding the Suv39h1 f/f mice to the Lrat-Cre mice or the Postn-CreERT2 mice.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators constructed high-resolution spatial transcriptomes of liver biopsies containing 13,059 tissue spots from 18 patients with chronic hepatitis B virus infection to analyse the occurrence and relative distribution of transcriptionally active viral integration events.
[Gut] |
| | Researchers performed single-nucleus RNA-sequencing in hepatocyte nuclei of different ploidy levels isolated from young and old wild-type mice. Changes in the gene expression and regulatory network were compared to three independent haploinsufficient strains for HNF4A, CEBPA, or CTCF.
[Journal Of Hepatology] |
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| Scientists identified a continuum of hepatoblastoma cell states between hepatocytic, liver progenitor, and mesenchymal differentiation poles, with an intermediate scH/LP population bordering scLP and scH areas in spatial transcriptomics.
[Nature Communications] |
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| By following the early stages of this process, investigators observed dramatic programmed changes in the DNA methylation profile, characterized by both de novo and demethylation events, with a subsequent return to the original adult pattern as the liver matures.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors revealed that Cyclic GMP–AMP synthase (cGAS) was significantly downregulated in clinical HCC tissues, and its dysregulation contributed to the progression of HCC.
[Cell Death & Differentiation] |
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| Scientists performed proteomic analysis of this model to elucidate its proteomic characteristics. Compared with normal liver tissues, 432 differentially expressed proteins were identified in tumor tissues, among which 365 were up-regulated and 67 were down-regulated.
[Scientific Reports] |
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| Researchers investigated the the roles and mechanisms of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), and entecavir on the malignant characteristics of liver cancer cells.
[Scientific Reports] |
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| The combination of liver transcriptomics and metabolomics analysis revealed that linoleic acid (LA) metabolism, a pivotal pathway in fatty acids metabolism was mainly manipulated during the induction and treatment of nonalcoholic fatty liver disease.
[Heliyon] |
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| Metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis, has emerged as the most common chronic liver disease worldwide and a leading cause of HCC.
[Clinical Gastroenterology And Hepatology] |
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| Eureka Therapeutics, Inc., a clinical-stage biotechnology company developing novel T cell therapies to treat cancer, announced the activation of UCSF Benioff Children’s Hospitals as the first California site to join the ARYA-2 clinical trial.
[Eureka Therapeutics, Inc.] |
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| Blue Faery: The Adrienne Wilson Liver Cancer Association announced the annual Blue Faery Award (BFA) for Excellence in Liver Cancer Research. Primary liver cancer, also known as HCC, is the third leading cause of cancer deaths worldwide.
[Blue Faery (PR Newswire, Inc.)] |
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| May 29 – June 1, 2024
Vancouver, British Columbia, Canada |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Duke University School of Medicine – Durham, North Carolina, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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