 | | Vol. 8.11 – 19 April, 2024 |
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| This integrative study dissected in detail the molecular gradients controlling liver cell function, systematically defining how gene networks were dynamically modulated through intercellular communication to promote regeneration.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators noted thrombocytopenia in mice with hepatic Notch1 deficiency, and so investigated thrombopoietin production and other features of platelets in mice. They found that the liver ultrastructure and hepatocyte function were comparable between control mice and Notch1-deficient mice.
[Blood] |
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| Scientists examined the role of sterol regulatory element-binding protein (SREBP)-1c in nonalcoholic steatohepatitis and the regulation of lipocalin-2 (LCN2) gene expression. Wild-type and SREBP-1c knockout mice were fed a high-fat/high-sucrose diet and subjected to LCN2 overexpression.
[Experimental & Molecular Medicine] |
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| Researchers established a direct link between skeletal muscle homeostasis and hepatic metabolism. Dietary and anti-inflammatory interventions that restored ketogenesis may be a viable preventative approach for pre-cachectic patients with pancreatic cancer.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Scientists evaluated the utility of tumor content in circulating cell-free DNA for monitoring HCC throughout its natural history. They included 67 hepatitis B virus-related HCC patients, of whom 17 had paired pre- and post-treatment samples, and 90 controls.
[Clinical Cancer Research] |
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| A multicenter, retrospective, and observational study was conducted. During the overall follow-up of five years, HCC patients who had curative resection were monitored every three months in the first year post-surgery and every six months thereafter if no recurrence occurred.
[Scientific Reports] |
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| The authors propose that chronic endoplasmic reticulum stress is a common transversal factor contributing to the transition from liver disease to HCC. Interventional strategies to target the unfolded protein response in HCC as cancer therapy are also discussed.
[Hepatology] |
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| By all accounts, the US should be able to eliminate viral hepatitis, but instead, new cases are on the rise, largely due to the opioid epidemic and increasing viral hepatitis transmission through injection drug use.
[Stat] |
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| May 20, 2024
New York, New York, United States & Online |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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