Human Immunology New Volume 9.00 | Jan 5 2021

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    HIN 9.00 | Jan 5 2021


    Human Immunology News by STEMCELL Technologies
    Vol. 9.00 – 5 January, 2021
    TOP STORY

    Liver
    Metastasis Restrains Immunotherapy Efficacy via Macrophage-Mediated T Cell Elimination

    Researchers report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models. Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response.
    [Nature Medicine]

    Abstract

    Virtual Conference Exhibition: Immunology
    PUBLICATIONSRanked by the impact factor of the journal

    Intracellular
    Immune Sensing Promotes Inflammation via Gasdermin D–Driven Release of a Lectin Alarmin

    Scientists revealed that cytosolic lipopolysaccharide sensing triggered the release of galectin-1, a β-galactoside-binding lectin. They also found increased galectin-1 in sera from human patients with sepsis.
    [Nature Immunology]

    Abstract

    Combination
    of Anti-PD-1 Antibody with P-GEMOX as a Potentially Effective Immunochemotherapy for Advanced Natural Killer/T Cell Lymphoma

    The authors report the efficacy of anti-programmed death 1 antibody with the P-GEMOX (pegaspargase, gemcitabine, and oxaliplatin) regimen in advanced natural killer/T cell lymphoma.
    [Signal Transduction and Targeted Therapy]

    Full Article

    MBD2
    Serves as a Viable Target against Pulmonary Fibrosis by Inhibiting Macrophage M2 Program

    Depletion of Mbd2 in macrophages protected mice against bleomycin-induced pulmonary fibrosis. Mbd2 deficiency significantly attenuated transforming growth factor–β1 production and reduced M2 macrophage accumulation in the lung following bleomycin induction.
    [Science Advances]

    Full Article

    Single-Cell
    Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells

    Scientists combined bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and hematopoietic stem-progenitor cells from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurred progressively along a continuum of maturity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The
    Mutational Load and a T-Cell Inflamed Tumor Phenotype Identify Ovarian Cancer Patients Rendering Tumor-Reactive T Cells from PD-1+ Tumor-Infiltrating Lymphocytes

    Tumor-reactive tumor-infiltrating lymphocytes were detected in half of patients and were exclusively present in cells derived from the PD-1+ fraction.
    [British Journal of Cancer]

    Full Article

    Single-Cell
    Profiling of the Human Decidual Immune Microenvironment in Patients with Recurrent Pregnancy Loss

    Investigators profiled the respective transcriptomes of 18,646 primary human decidual immune cells isolated from patients with recurrent pregnancy loss and healthy controls at single-cell resolution.
    [Cell Discovery]

    Full Article

    Skin T Cells Maintain Their Diversity and Functionality in the Elderly

    Researchers assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries.
    [Communications Biology]

    Full Article

    Chronic
    Lymphocytic Leukemia B Cell Derived TNFα Impairs Bone Marrow Myelopoiesis

    Scientists showed that co-culture of chronic lymphocytic leukemia B cells with purified normal human hematopoietic stem and progenitor cells (HSPCs) directly altered protein levels of the myeloid and erythroid cell fate determinants PU.1 and GATA-2 at the single cell level within transitional HSPC subsets, mimicking ex vivo expression patterns.
    [iScience]

    AbstractFull Article
    Graphical Abstract

    Explore scientific events this January with the Science Events Calendar.
    REVIEWS

    Cancer Stemness Meets Immunity: From Mechanism to Therapy

    The authors review the cellular and molecular mechanisms underlying the symbiotic interactions between cancer stem cells and immune cells and how such heterotypic signaling maintains a tumor-promoting ecosystem and informs therapeutic strategies intercepting this co-dependency.
    [Cell Reports]

    Full Article

    Emerging
    Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

    Scientists reveal the development of a highly promising therapeutic approach for cancer immunotherapy by targeting PD-1/PD-L1 ubiquitination.
    [Molecular Therapy]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Incyte and Cellenkos Enter into Global Development Collaboration Agreement for CK0804

    Incyte and Cellenkos, Inc. announced a development collaboration to investigate the combination of ruxolitinib and CK0804, Cellenkos’ cryopreserved CXCR4 enriched, allogeneic, umbilical cord blood-derived T-regulatory cells, in patients with myelofibrosis.
    [Incyte (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Vision 2030 A Forecast for the Field

    January 7 – 8, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Associate – Tumor Immune Microenvironment

    University of Florida – Gainesville, Florida, United States

    Research Scientist – Tumor Microenvironment

    Systimmune, Inc. – Redmond, Washington, United States


    Postdoctoral Researcher – Single-Cell Immunology

    Karolinska Institutet – Huddinge, Sweden

    Postdoctoral
    Research – Innate Immunity & Endothelial Permeability

    University of Illinois at Chicago – Chicago, Illinois, United States

    Research
    Associate / Assistant – Immuno-Oncology

    Scripps Research Institute – La Jolla, California, United States

    > See All Jobs

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