| TOP STORY | HHLA2 Is a Member of the B7 Family and Inhibits Human CD4 and CD8 T-Cell Function T-cell costimulation and coinhibition generated by engagement of the B7 family and their receptor CD28 family are of central importance in regulating the T-cell response, making these pathways very attractive therapeutic targets. The authors describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family. [Proc Natl Acad Sci USA] Abstract |
| REVIEWS | Human Dendritic Cell Subsets in Vaccination Dendritic cells (DCs) are at the center of the immune system owing to their ability to control both tolerance and immunity. DCs are thus key targets for both preventive and therapeutic vaccination. Herein, the authors discuss recent progresses in their understanding of DC subsets physiology as it applies to vaccination. [Curr Opin Immunol] Abstract Monitoring the Immune Response in Sepsis: A Rational Approach to Administration of Immunoadjuvant Therapies There is an urgent need for robust biomarkers usable in routine conditions evaluating rapidly evolving immune status in patients. Although functional testing remains a gold standard, its standardization remains challenging. Therefore, surrogate markers such as monocyte HLA-DR expression, are being developed. Such biomarkers of immune functionality will enable a novel approach in the design of clinical trials evaluating immunostimulating therapies in sepsis at the right time and in the right patient. [Curr Opin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. |
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