| PUBLICATIONS (Ranked by impact factor of the journal) | Evidence that Autophagy, But Not the Unfolded Protein Response, Regulates the Expression of IL-23 in the Gut of Patients with Ankylosing Spondylitis and Subclinical Gut Inflammation Scientists examined the mechanisms underlying the increased IL-23 expression in the gut of ankylosing spondylitis (AS) patients. Consecutive gut biopsies from 30 HLA-B27+ AS patients, 15 Crohn’s disease patients and 10 normal subjects were obtained. Evidence for HLA-B27 misfolding was studied. Unfolded protein response (UPR) and autophagy were assessed by RT-PCR and immunohistochemistry. The contribution of UPR and autophagy in the regulation of interleukin (IL)-23 expression was evaluated in in vitro experiments on isolated lamina propria mononuclear cells. [Ann Rheum Dis] Abstract Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase I Trial in Multiple Sclerosis Researchers assessed the feasibility, safety, and tolerability of a tolerization regimen in multiple sclerosis (MS) patients that uses a single infusion of autologous peripheral blood mononuclear cells chemically coupled with seven myelin peptides. An open-label, single-center, dose-escalation study was performed in seven relapsing-remitting and two secondary progressive MS patients who were off-treatment for standard therapies. [Sci Transl Med] Abstract | Press Release Dual Receptor T Cells Mediate Pathologic Alloreactivity in Patients with Acute Graft-versus-Host Disease Scientists demonstrated that the small subset of peripheral T cells that naturally express two T cell receptors on the cell surface contributes disproportionately to acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. [Sci Transl Med] Abstract Interleukin 17F Level and Interferon Beta Response in Patients with Multiple Sclerosis The authors investigated the role of interleukin (IL) 17F in predicting treatment response to interferon beta-1b in patients with relapsing-remitting multiple sclerosis using the Singulex Erenna IL-17F immunoassay. [JAMA Neurol] Abstract | Press Release CRYAB Modulates the Activation of CD4+ T Cells from Relapsing-Remitting Multiple Sclerosis Patients Researchers assessed whether the ability of CRYAB to reduce the activation of T cells translated to the human disease. CD4+ T cells from healthy controls and volunteers with multiple sclerosis were activated in vitro in the presence or absence of a CRYAB peptide. Parameters of activation (proliferation rate, cytokine secretion) and tolerance (anergy, activation-induced cell death, microRNAs) were evaluated. [Mult Scler] Abstract DcR3 Mutations in Patients with Juvenile-Onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation Scientists investigated the role of death decoy receptor 3 (DcR3) in juvenile-onset systemic lupus erythematosus (SLE), to identify polymorphisms that might alter the function of this protein. DcR3 was measured in the serum of 61 patients with juvenile SLE. [J Rheumatol] Abstract Anti-Tumor Necrosis Factor Therapy Enhances Mucosal Healing through Down-Regulation of Interleukin-21 Expression and T Helper Type 17 Cell Infiltration in Crohn’s Disease Researchers investigated the potential role of anti-tumor necrosis factor monoclonal antibody in inducing clinical remission and regulating interleukin-21 expression and T helper type 17 cell infiltration in the intestinal mucosa of Crohn’s disease patients. [Clin Exp Immunol] Abstract Hydrogen Sulfide Inhibits Abnormal Proliferation of Lymphocytes via AKT/GSK3β Signal Pathway in Systemic Lupus Erythematosus Patients Recently Hydrogen sulfide (H2S) has been recognized as a crucial gaseous signaling molecule, involved in regulation of cell proliferation. However, the role of H2S in regulating the abnormal activation of lymphocytes from systemic lupus erythematosus patients has not been established. Researchers investigated the effect of H2S on lymphocytes and explored the mechanisms involved. [Cell Physiol Biochem] Full Article Don’t forget to subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |
| REVIEWS | The Arrival of JAK Inhibitors: Advancing the Treatment of Immune and Hematologic Disorders Inhibition of tyrosine kinase enzymatic activity using small molecules has recently become a powerful tool for treatment of several malignancies. Twenty years after the discovery of these enzymes, two inhibitors for this class of kinases have been approved for clinical use and others are currently in the final stage of development. The authors review the principles of cytokines signaling, summarize their current knowledge of the approved inhibitors, and briefly introduce some of the inhibitors that are currently under development. [BioDrugs] Abstract Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases This review summarizes and highlights the role and the modulatory effects of melatonin in several inflammatory autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and inflammatory bowel disease. [Int J Mol Sci] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. |
| INDUSTRY NEWS | NeoStem’s Subsidiary, PCT, Enters into a Manufacturing Agreement with ImmunoCellular Therapeutics, Ltd. for Dendritic Cell Vaccines Targeting Brain and Other Cancers NeoStem, Inc., its subsidiary, Progenitor Cell Therapy LLC (PCT), and ImmunoCellular Therapeutics, Ltd. (IMUC) announced the execution of a Services Agreement under which PCT will provide current good manufacturing practices manufacturing services to support research and development of IMUC’s ICT-121 cell therapy product candidate, a dendritic cell vaccine targeting CD133 cells. [ImmunoCellular Therapeutics, Ltd.] Press Release Neumedicines Receives an Award of $8.3 Million from BARDA for Continued Development of HemaMax as a Countermeasure to Acute Radiation Exposure Neumedicines Inc. announced the award of $8.3 million from the Biomedical Advanced Research & Development Authority (BARDA) of the U.S. Department of Health and Human Services for the continued development of HemaMax™ (recombinant human interleukin 12) for hematopoietic syndrome of acute radiation sickness. This award is based on the exercise of Option 1 of the existing contract with BARDA for advanced development of HemaMax™. [Business Wire] Press Release |
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