| PUBLICATIONS (Ranked by impact factor of the journal) | Cross-Validation of IFN-γ Elispot Assay for Measuring Alloreactive Memory/Effector T Cell Responses in Renal Transplant Recipients Assessment of donor-specific alloreactive memory/effector T cell responses using an IFN-γ Elispot assay has been suggested to be a novel immune-monitoring tool for evaluating the cellular immune risk in renal transplantation. Here, investigators report the cross-validation data of the IFN-γ Elispot assay performed within different European laboratories taking part of the EU RISET consortium. [Am J Transplant] Abstract An Age-Related Numerical and Functional Deficit in CD19+CD24hiCD38hi B Cells Is Associated with an Increase in Systemic Autoimmunity Scientists found the frequency and numbers of CD19+CD24hiCD38hi cells were reduced in the PBMC pool with age. IL10 expression and secretion following activation via either CD40, or Toll-like receptors was also impaired in CD19+CD24hiCD38hi B cells from healthy older donors. [Aging Cell] Abstract | Full Article Doxycycline Suppresses Chlamydia pneumoniae-Mediated Increases in Ongoing Immunoglobulin E and Interleukin-4 Responses by Peripheral Blood Mononuclear Cells of Patients with Allergic Asthma Peripheral blood mononuclear cells (PBMCs) from serum IgE+ allergic asthmatic subjects and healthy controls were infected with C. pneumoniae and cultured for 12 days with or without doxycycline. IgE, interferon-γ and interleukin-4 levels in supernatants were determined on days 1-12 post-infection, and C. pneumoniae DNA copy numbers in PBMC culture were measured on day two. [J Antimicrob Chemother] Abstract Control of Humoral Immunity and Auto-Immunity by the CXCR4/CXCL12 Axis in Lupus Patients following Influenza Vaccine The authors investigated whether the levels of CXCR4 expressed on leukocyte subsets in lupus patients are correlated with the efficacy and the safety of the influenza vaccine. Twenty-seven patients were vaccinated and vaccine immunogenicity and tolerance were evaluated. CXCR4 was assayed on leukocyte subsets and correlated with clinical and immunological signs of disease activity. [Vaccine] Abstract Increased CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells Correlate with Extrathoracic Metastasis and Poor Response to Chemotherapy in Non-Small Cell Lung Cancer Patients Researchers characterized peripheral CD14+HLA-DR-/low, a new human myeloid-derived suppressor cell subpopulation, in 89 patients with non-small cell lung cancer (NSCLC). As expected, both frequency and absolute number of CD14+HLA-DR-/low cells were significantly increased in the peripheral blood of NSCLC patients compared with that of the healthy controls and indicated an association with metastasis, response to chemotherapy, and progression-free survival. [Cancer Immunol Immunother] Abstract Defective Expression and Function of the ILT2/CD85j Regulatory Receptor in Dendritic Cells from Patients with Systemic Lupus Erythematosus Scientists evaluated the expression and function of ILT2 in dendritic cells (DCs) from systemic lupus erythematosus (SLE patients). Peripheral blood from fifty patients with SLE and 38 healthy volunteers was obtained. ILT2 expression was assessed by flow cytometry. DCs were generated in the absence or presence of an anti-ILT2 antibody. The effect of ILT2 in the immunogenic ability of SLE DCs was also evaluated. [Hum Immunol] Abstract Wnt5a Stimulates Chemotactic Migration and Chemokine Production in Human Neutrophils Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (ß-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils with Wnt5a caused chemotactic migration and the production of two important chemokines, CXCL8 and CCL2. [Exp Mol Med] Full Article Don’t forget to subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |
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