Immunoregulatory Pathways Are Active in the Small Intestinal Mucosa of Patients with Potential Celiac Disease Scientists investigated in the small intestinal mucosa of patients the state of immunological activation with special emphasis on immunoregulatory circuits. Duodenal biopsies from active celiac disease (CD), potential CD, and control patients were studied. [Am J Gastroenterol] Abstract Activated Platelets Enhance IL-10 Secretion and Reduce TNF-α Secretion by Monocytes Investigators examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid, human thyroglobulin, Escherichia coli LPS, or intact Porphyromonas gingivalis. [J Immunol] Abstract Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a Complement protein C5a, acting via C5aR, is shown to differentially modulate LPS-induced inflammatory responses in primary human monocytes versus macrophages. Whereas C5a enhanced secretion of LPS-induced IL-6 and TNF from primary human monocytes, C5a inhibited these responses while increasing IL-10 secretion in donor-matched human monocyte-derived macrophages differentiated by GM-CSF or M-CSF. [J Immunol] Abstract IL-22/IL-22R1 Axis and S100A8/A9 Alarmins in Human Osteoarthritic and Rheumatoid Arthritis Synovial Fibroblasts Researchers investigated whether the microenvironment of inflamed joints could modulate the expression of IL-22 and IL-22R1 on osteoarthritis and rheumatoid arthritis fibroblast-like synoviocytes (FLSs). They also examined the effect of IL-22 on FLS activation as well as on their IL-17-related responses. [Rheumatology] Abstract Multiple Infusions of CD20-Targeted T Cells and Low-Dose IL-2 after SCT for High-Risk Non-Hodgkin’s Lymphoma: A Pilot Study A pilot phase I clinical trial involving 15 infusions of anti-CD3 × anti-CD20 bispecific Ab-armed anti-CD3-activated T cells (aATC) and low-dose IL-2 was conducted in three non-Hodgkin’s lymphoma patients after autologous SCT. The feasibility of T-cell expansion, safety of aATC infusions, cytotoxic immune responses and trafficking of aATC were evaluated. [Bone Marrow Transplant] Abstract Association of IL-6, TNF-α and IL-10 Gene Polymorphisms with Type 2 Diabetes Mellitus Polymorphism of cytokine genes including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) were studied in type 2 diabetes mellitus (T2DM) patients as well as in normal healthy controls. Genomic DNA was isolated from both T2DM patients and controls followed by quantification and genotyping by polymerase chain reaction-restriction fragment length polymorphism using suitable primers. [Mol Biol Rep] Abstract Targeting of Memory T Cells with Alefacept in New-Onset Type 1 Diabetes (T1DAL Study): 12 Month Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigators postulated that alefacept would arrest autoimmunity and preserve residual β cells in patients newly diagnosed with type 1 diabetes. The T1DAL study is a phase II, double-blind, placebo-controlled trial in patients with type 1 diabetes, aged 12-35 years who, within 100 days of diagnosis, were enrolled at 14 US sites. [Lancet Diabetes Endocrinol] Abstract | Press Release |