Antigen-Specific Expansion of Human Regulatory T Cells as a Major Tolerance Mechanism against Mucosal Fungi Scientists used a sensitive enrichment technology for antigen-reactive T cells to directly compare the conventional vs. regulatory CD4+ T-cell response directed against two ubiquitous mucosal fungi, Aspergillus fumigatus and Candida albicans. [Mucosal Immunol] Abstract Circulating Levels of Soluble MER in Lupus Reflect M2c Activation of Monocytes/Macrophages, Autoantibody Specificities and Disease Activity Investigators aimed to determine if shedding of MER receptor tyrosine kinase and AXL into soluble(s) ectodomains was related to immunological and clinical aspects of systemic lupus erythematosus. [Arthritis Res Ther] Abstract | Full Article Cytokine and Chemokine Patterns Across One Hundred Days following Hematopoietic Stem Cell Transplantation in Children Researchers mapped the cytokine response to hematopoietic stem cell transplantation (HSCT) by assaying fifty-one cytokines and chemokines each week for one hundred days in fifty-one children receiving allogeneic or autologous HSCT. [Biol Blood Marrow Transplant] Abstract Impact of Alemtuzumab Treatment on the Survival and Function of Human Regulatory T Cells In Vitro Since regulatory T (Treg) cells play an important role in the control of autoimmune responses, the effect of alemtuzumab on Treg cells was further studied in vitro. Alemtuzumab effectively mediated complement-dependent cytolysis of human T lymphocytes and the remaining population was enriched in T cells with a regulatory phenotype. [Immunology] Abstract Oral Vitamin D Increases the Frequencies of CD38+ Human B Cells and Ameliorates IL-17 Producing T Cells The authors assessed whether oral vitamin D supplementation leads to a systemic modulation of the phenotype of circulating lymphocyte populations and whether a defined serum 25-hydroxyvitamin D concentration can be related to the effects on lymphocytes. [Exp Dermatol] Abstract Properties of Human Blood Monocytes. II. Monocytes from Healthy Adults Are Highly Heterogeneous within and among Individuals Blood samples from 200 healthy adults without known immunological abnormalities were examined by analysis with a hematology analyzer and by flow cytometry to determine leukocyte differential counts, to identify subsets and to measure expression of monocyte-associated molecules. [Cytometry B Clin Cytom] Abstract Decreased Plasma IL-22 Levels and Correlations with IL-22-Producing T Helper Cells in Patients with New-Onset Systemic Lupus Erythematosus Plasma levels of IL-22 were measured in 41 systemic lupus erythematosus (SLE) patients and 20 healthy controls by enzyme-linked immunosorbent assay (ELISA). Meanwhile, the percentages of CD4+IFN-γ+, CD4+IL-17+ and CD4+IFN-γ-IL-17- IL-22+ cells in peripheral lymphocytes were determined by flow cytometry and plasma IL-22 autoantibodies were detected by ELISA in 19 new-onset SLE patients and 20 healthy controls. [Scand J Immunol] Abstract |