Human Immunology News Volume 10.08 | March 1 2022

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    2022-03-01 | HIN 10.08


    Human Immunology News by STEMCELL Technologies
    Vol. 10.08 – 1 March, 2022
    TOP STORY

    Increased Cytotoxic T Cells in the Airways of Adults with Former Bronchopulmonary Dysplasia

    The total number of cells and the differential cell counts in bronchoalveolar lavage were similar among the study groups.
    [European Respiratory Journal]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    AKT2 Reduces IFNβ1 Production to Modulate Antiviral Responses and Systemic Lupus Erythematosus

    Scientists showed that the serine/threonine kinase AKT2 interacted with interferon regulatory factor 3 (IRF3) and phosphorylated it on Thr207, thereby attenuating IRF3 nuclear translocation in a 14-3-3ε-dependent manner and reducing induced type I interferon production.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Nanobodies as Allosteric Modulators of Parkinson’s Disease–Associated LRRK2

    Investigators reported the identification and characterization of a variety of nanobodies that bound to different leucine-rich repeat kinase 2 (LRRK2) domains and inhibited or activated LRRK2 in cells and in vitro.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Heritable Changes in Division Speed Accompany the Diversification of Single T Cell Fate

    Researchers utilized continuous live-cell imaging in vitro to track the division speed and genealogical connections of all descendants derived from a single naive CD8+ T cell throughout up to ten divisions of activation-induced proliferation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Epitope Length Variants Balance Protective Immune Responses and Viral Escape in HIV-1 Infection

    Scientists found that proteasomal activity generated multiple length variants of KK10, which bound TAP and human leukocyte antigen-B∗27:05.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Revealing the Transcriptional Heterogeneity of Organ-Specific Metastasis in Human Gastric Cancer Using Single-Cell RNA Sequencing

    Ten fresh human tissue samples from six patients, including primary tumor and adjacent non-tumoral samples and six metastases from different organs or tissues were evaluated using single-cell RNA sequencing.
    [Clinical and Translational Medicine]

    Full Article

    Antiplatelet Antibody Predicts Platelet Desialylation and Apoptosis in Immune Thrombocytopenia

    The authors used sera from 61 immune thrombocytopenia patients and assessed the capacity of antiplatelet antibodies to induce neuraminidase 1 surface expression, RCA-1 lectin binding and loss of mitochondrial inner membrane potential on donors’ platelets.
    [Haematologica]

    Abstract

    Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression

    Co-culturing primary CD8+ T cells with T regulatory cells only modestly affected the CD8+ surfaceome but did partially reverse activation-induced surfaceomic changes.
    [Molecular & Cellular Proteomics]

    AbstractGraphical Abstract

    IQCELL: A Platform for Predicting the Effect of Gene Perturbations on Developmental Trajectories Using Single-Cell RNA-Seq Data

    Researchers applied IQCELL to single cell RNA-seq datasets from early mouse T cell and red blood cell development, and showed that the platform could infer overall over 74% of causal gene interactions previously reported from decades of research.
    [PLoS Computational Biology]

    Full Article

    PD-1 Blockade Enhances Chemotherapy Toxicity in Oesophageal Adenocarcinoma

    Mechanistic insights demonstrated that blockade of the PD-1 axis decreased stem-like marker ALDH and expression of DNA repair genes.
    [Scientific Reports]

    Abstract

    Regulatory B Cells Are Decreased and Functionally Impaired in Myasthenia Gravis Patients

    Investigators found that the proportions of CD19+ IL-10+ cells and CD19+CD24hiCD38hi cell subsets in myasthenia gravis patients were significantly lower than those in healthy controls.
    [Frontiers in Neurology]

    Full Article

    Quantify Cytokines with Confidence with High-Performance ELISA Kits
    REVIEWS

    Innate Lymphoid Cells and Cancer

    The authors examine the pleiotropic behavior of innate lymphoid cel (ILCs) in cancer and begin to unravel the gap in our knowledge that exposes a new horizon for thinking about modifying ILCs and targeting them for immunotherapy.
    [Nature Immunology]

    Abstract

    Bystander T Cells in Cancer Immunology and Therapy

    Investigators discuss recent studies of bystander T cells in tumors, including experimental and computational approaches that enable their identification and functional analysis.
    [Nature Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    UC Berkeley Loses CRISPR Patent Case, Invalidating Patent Rights It Granted Gene-Editing Companies Developing Human Therapies

    Ending the latest chapter in a years-long legal battle over who invented CRISPR, the US Patent and Trademark Office ruled that the revolutionary genome editing technology belongs to the Broad Institute of Harvard and MIT.
    [STAT News]

    Editorial

    US Food and Drug Administration Accepts for Priority Review Bristol Myers Squibb’s Application for Opdivo (nivolumab) Plus Chemotherapy as Neoadjuvant Treatment for Resectable Non-Small Cell Lung Cancer

    Bristol Myers Squibb announced that the FDA has accepted the supplemental Biologics License Application for Opdivo plus chemotherapy for the neoadjuvant treatment of patients with resectable non-small cell lung cancer.
    [Bristol Myers Squibb]

    Press Release
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    JOB OPPORTUNITIES

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    University of Lausanne – Lausanne, Switzerland

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