 | | Vol. 10.09 – 8 March, 2022 |
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| CD8+ T expressing inhibitory killer cell immunoglobulin-like receptors cells efficiently eliminated pathogenic gliadin-specific CD4+ T cells from celiac disease patients’ leukocytes in vitro.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described the identification and characterization of INCB086550, a novel, oral, small-molecule programmed cell death protein 1 (PD-L1) inhibitor.
[Cancer Discovery] |
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| Researchers used spatial transcriptomics to examine the nature of B cell responses within tertiary lymphoid structures in renal cell carcinoma.
[Immunity] |
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| TET2 activation in B cells triggered by oxidative stress from the hepatocellular carcinoma (HCC) microenvironment promoted IL-10 expression, while the adoptive transfer of Tet2-deficient B cells suppressed HCC progression.
[Hepatology] |
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| Investigators applied selection strategies to enrich innate lymphoid cells (ILC) populations in hepatocellular carcinoma samples to investigate the effects of B cells on the immune reaction of ICOS+ ILC2 cells.
[Hepatology] |
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| In a Phase I/Ib, dose-escalation/expansion study, patients with advanced/metastatic non-small cell lung cancer and 1 prior therapy received taminadenant with or without spartalizumab.
[Clinical Cancer Research] |
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| Investigators performed co-culture assays to examine expression of Th2 cytokines by triple negative breast cancer cells with and without the presence of B cells.
[Journal of Translational Medicine] |
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| The authors investigated the effects of S1P receptor 1 (S1P1) specific S1P analogue SEW2871, S1P1 and S1P5 specific Siponimod (BAF312), and non-selective (fingolimod) FTY720 on human Th17 and Treg differentiation and IL-23-mediated signaling.
[International Immunopharmacology] |
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| Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.
[Nature Cancer] |
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| Dendritic cells consist of multiple subsets that reside in the epithelium, connective tissues, and major organs.
[Periodontology 2000] |
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| Expression levels of miR-630 can be used as markers for prediction of cancer course. Moreover, miR-630 can influence response to chemoradiotherapy.
[Cancer Cell International] |
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| Six Canadian research teams have been awarded funding for the implementation and/or continuation of sex and gender considerations in research on aging, neurodegeneration, and stroke.
[Brain Canada Foundation] |
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| BioNTech SE announced the expansion of its strategic collaboration with Regeneron to advance the company’s FixVac candidate BNT116 in combination with Libtayo®, a PD-1 inhibitor, in advanced non-small cell lung cancer.
[BioNTech SE] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | Amsterdam UMC – Amsterdam, Netherlands |
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| | BioNTech – Gaithersburg, Maryland, United States |
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| | National Institute for Health and Medical Research – Paris, France |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | University of Lausanne – Lausanne, Switzerland |
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