 | | Vol. 10.33 – 23 August, 2022 |
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| Scientists elucidated a shared biochemical function of laccase domain-containing 1 (LACC1) in mice and humans, converting L-citrulline to L-ornithine and isocyanic acid and serving as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used cryogenic electron microscopy to determine the structure of a tumor-reactive T cell receptor αβ/CD3δγε2ζ2 complex bound to a melanoma-specific human class I pMHC at 3.08 Å resolution.
[Cell] |
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| The authors conducted a large-scale transcriptome study with 6,386 RNA sequencing data covering 27 immune cell types from 136 systemic lupus erythematosus and 89 healthy donors.
[Cell] |
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| In humans with rheumatoid arthritis, JMJD1C expression levels in B cells were negatively associated with plasma cell frequency and disease severity.
[Nature Immunology] |
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| Scientists demonstrated that, although CTLA-4 targeted both CD80 and CD86 for destruction via transendocytosis, this process resulted in separate fates for CTLA-4 itself.
[Nature Immunology] |
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| The authors presented a modified high-throughput, culture-independent approach to quantify systemic immunoglobulin G (IgG) against gut commensal bacteria in human serum samples without the need for paired stool samples.
[Science Translational Medicine] |
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| Researchers indicated that metabolic insults caused by a high-fat and high-fructose diet elicited liver damage and promoted pathogenic immune autoreactivity driven by T and B cell protein disulfide isomerase family A member 3 (PDIA3) epitopes.
[Science Immunology] |
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| Investigators showed that interferon regulatory factor 8 (IRF8) was essential for efficient activation of STING-mediated innate immune responses in monocytes.
[Nature Communications] |
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| Multiplex immunohistochemistry was used to quantify in situ biomarkers at sub-cellular resolution in 80 patients with gastric cancer.
[Nature Communications] |
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| Researchers observed that CD36 and NLR family pyrin domain containing 3 (NLRP3) were upregulated in the podocytes of lupus nephritis patients and MRL/lpr mice with renal impairment.
[Cell Death & Disease] |
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| The authors studied neuraminidase activity and expression in mature human neutrophils (PMNs) and the HL60 promyelocytic leukemic cell line, and changes that might have occurred in PMNs undergoing apoptosis and HL60 cells during their differentiation into PMN-like cells.
[Scientific Reports] |
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| Investigators provide a concise review of the development and physiological role of CD8+ resident memory T cells, their involvement in diseases, and their potential therapeutic exploitation.
[Science Advances] |
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| Scientists investigate the results of various articles on the role of natural killer (NK) cells in allogeneic hematopoietic cell transplantation and also their exosomes in graft-versus-leukemia.
[Stem Cell Reviews and Reports] |
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| The authors classify cancer vaccines by what is known of the included antigens, which tumors express those antigens, and where the antigens colocalize with antigen-presenting cells, thus delineating predefined vaccines and anonymous vaccines.
[Nature Cancer] |
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| Innovative Cellular Therapeutics, Inc. announced that the first patient has been enrolled in its Phase I trial of GCC19CART for relapsed/refractory metastatic colorectal cancer.
[Innovative Cellular Therapeutics, Inc.] |
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| The National Foundation for Cancer Research announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research.
[National Foundation for Cancer Research] |
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| November 12 – 16, 2022
San Diego, California, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | NYU Langone Health – New York, New York, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | National Research Council Canada – Toronto, Ontario, Canada |
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| | Duke University – Durham, North Carolina, United States |
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