 | | Vol. 10.38 – 27 September, 2022 |
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| Using in vitro systems, scientists found that tumor stromal components, including fibroblasts and collagen, cooperated to blunt radiation therapy (RT) efficacy and impair RT-induced interferon signaling.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Plasma and blood neutrophils were assessed for proteinase 3 (PR3) and α1-antitrypsin (AAT). Wild-type, mutant, and oxidation-resistant AAT species were produced to characterize AAT-PR3 interactions by flow cytometry, immunoblotting, FRET assays, and surface plasmon resonance measurements.
[Journal of Clinical Investigation] |
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| The authors performed flow cytometry, single-cell RNA sequencing, and B cell receptor sequencing of primary central nervous system lymphoma cells released from biopsy material, blood, and cerebrospinal fluid, and spatial transcriptomics of biopsy samples.
[Genome Medicine] |
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| The differential abundances of tumor-infiltrating lymphocytes subset populations were characterized through immunohistochemical staining of formalin-fixed, paraffin-embedded samples from a training cohort, which was a subset of the RNA-Seq cohort.
[Clinical Cancer Research] |
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| Researchers used high-dimensional mass cytometry in baseline blood samples of advanced non-small cell lung cancer patients treated with pembrolizumab to evaluate circulating immune predictors of pembrolizumab efficacy.
[Clinical Cancer Research] |
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| Ten patients from a phase I clinical trial who had received modified immune cells infusions before kidney transplantation were followed to posttransplant day 1080.
[Journal of the American Society of Nephrology] |
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| Scientists demonstrated through a series of experiments that TICRR facilitated the proliferation and metastasis of liver cancer cells in vitro.
[Molecular Therapy-Nucleic Acids] |
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| Researchers deep sequenced the TCR-β chain repertoires from longitudinal peripheral blood DNA samples at four time points beginning early in life from children who progressed to type 1 diabetes and age/sex-matched islet autoantibody-negative controls.
[JCI Insight] |
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| The authors developed a model that could predict the CD34+ harvest volume on the first day of apheresis based on PB-CD34+ counts immediately prior to commencing apheresis in pediatric population.
[Bone Marrow Transplantation] |
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| Investigators provide an overview of innate immunity from a biophysical perspective, review the biophysical factors that affect the innate immune system, and then explore innate immune cell biophysics in the context of migration, phagocytosis, and phenotype polarization.
[APL Bioengineering] |
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| IN8bio, Inc. a clinical-stage biopharmaceutical company developing gamma-delta T-cell therapies that utilize its DeltEx platform, has selected the UofL Health – Brown Cancer Center GMP Manufacturing Facility at the University of Louisville as its manufacturing partner for INB-400.
[University of Louisville] |
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| Six researchers received a KCA Trailblazer Award, which is a new award category this year and funds promising young- to mid-career investigators to foster innovative kidney cancer research.
[Kidney Cancer Association] |
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| Novemeber 17 – 18, 2022
Lisbon, Portugal |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| | Cardiff University – Cardiff, Wales, United Kingdom |
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| | Salk Institute – La Jolla, California, United States |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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