Human Immunology News Volume 10.42 | Oct 25 2022

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    2022-10-25 | HIN 10.42


    Human Immunology News by STEMCELL Technologies
    Vol. 10.42 – 25 October, 2022
    TOP STORY

    Silencing EGFR-Upregulated Expression of CD55 and CD59 Activates the Complement System and Sensitizes Lung Cancer to Checkpoint Blockade

    The authors demonstrated that epidermal growth factor receptor (EGFR)/Wnt signaling induced β-catenin-mediated long noncoding RNA LINC00973 expression to sponge CD55-targeting miR-216b and CD59-targeting miR-150.
    [Nature Cancer]

    Abstract
    Who does immunology research in the Bolivian Andes? He does. Read Jason Young's story.
    PUBLICATIONSRanked by the impact factor of the journal

    An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas

    Investigators showed that B cells expressing Myd88L252P activated, proliferated, and differentiated, with minimal T cell co-stimulation.
    [Cancer Discovery]

    Abstract

    Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

    Scientists designed B7-H3-specific chimeric antigen receptor (CAR) T cells, confirmed their preclinical efficacy, and opened BrainChild-03, a first-in-human Phase I trial employing repeated locoregional B7-H3CARs to children with recurrent central nervous system tumors and diffuse intrinsic pontine glioma.
    [Cancer Discovery]

    Abstract

    CMTM4 Is a Subunit of the IL-17 Receptor and Mediates Autoimmune Pathology

    Both mouse and human cell lines deficient in CMTM4 were largely unresponsive to IL-17A, due to their inability to assemble the IL-17R signaling complex.
    [Nature Immunology]

    Full Article

    IL-17D-Induced Inhibition of DDX5 Expression in Keratinocytes Amplifies IL-36R-Mediated Skin Inflammation

    Researchers found that the RNA helicase DDX5 was downregulated in keratinocytes from the inflammatory skin lesions in patients with atopic dermatitis and psoriasis, and that mice with keratinocyte-specific deletion of Ddx5 were more susceptible to cutaneous inflammation.
    [Nature Immunology]

    Full Article

    Human Neutrophil Development and Functionality Are Enabled in a Humanized Mouse Model

    Investigators generated a humanized mouse model named MISTRGGR, in which the mouse granulocyte colony-stimulating factor (G-CSF) was replaced with human G-CSF and the mouse G-CSF receptor gene was deleted in existing MISTRG mice.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Responsiveness to Interleukin-15 Therapy Is Shared between Tissue-Resident and Circulating Memory CD8+ T Cell Subsets

    The authors reported that IL-15 complexes stimulated rapid proliferation and expansion of both tissue-resident and circulating memory CD8+ T cell subsets across lymphoid and nonlymphoid tissues with varying magnitude by tissue and memory subset, in some sites correlating with differing levels of the IL-2Rβ.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    NLRP6 Is Required for Cancer-Derived Exosome-Modified Macrophage M2 Polarization and Promotes Metastasis in Small Cell Lung Cancer

    Investigators found that high expression of the alternatively activated tumor-associated macrophage marker, CD206+ was associated clinically with a poorer prognosis and metastasis state in patients with small cell lung cancer.
    [Cell Death & Disease]

    Full Article

    HDAC6-Dependent Deacetylation of TAK1 Enhances sIL-6R Release to Promote Macrophage M2 Polarization in Colon Cancer

    Researchers showed that the infiltration ratio of M2 macrophages was increased in colon cancer tissues with high histone deacetylase 6 (HDAC6) expression. Similarly, the knockdown of HDAC6 in colon cancer cells inhibited cocultured macrophage M2 polarization in vitro.
    [Cell Death & Disease]

    Full Article

    Non-Heme Iron Overload Impairs Monocyte to Macrophage Differentiation via Mitochondrial Oxidative Stress

    The authors used an in vitro model of monocyte-to-macrophage differentiation to study the effect of iron overload on macrophage function.
    [Frontiers in Immunology]

    Full Article

    Deconvolution of Bulk Tumors into Distinct Immune Cell States Predicts Colorectal Cancer Recurrence

    Scientists predicted colorectal cancer recurrence based on cellular deconvolution of bulk tumors into two distinct immune cell states: cancer-associated and noncancer-associated.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Different Antibody-Associated Autoimmune Diseases Have Distinct Patterns of T Follicular Cell Dysregulation

    Investigators found that the frequency of circulating T follicular subsets differed across diseases. Patients with Hashimoto’s thyroiditis (HD) had an increased frequency of blood T follicular helper cells and a reduced Tfr/Tfh ratio when compared with HD.
    [Scientific Reports]

    Full Article

    Multiplexed Imaging Mass Cytometry Reveals Distinct Tumor-Immune Microenvironments Linked to Immunotherapy Responses in Melanoma

    The authors used imaging mass cytometry to simultaneously quantify 35 proteins in a spatially resolved manner on tumor tissues from 26 melanoma patients receiving anti-programmed cell death-1 therapy.
    [Communications Medicine]

    Full Article
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    REVIEWS

    Long Non-Coding RNA: Multiple Effects on the Differentiation, Maturity and Cell Function of Dendritic Cells

    Investigators summarize the impact of pathological factors and physiological factors on the LncRNAs in dendritic cells (DCs), and how the changed LncRNAs altered the function and behavior of DCs resulting from the intervention.
    [Clinical Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Alpine Immune Sciences Terminates Enrollment of Davoceticept Clinical Studies (NEON-1 and NEON-2)

    Alpine Immune Sciences, Inc. announced that the xompany has voluntarily terminated enrollment in both clinical studies involving davoceticept, an investigational CD28 costimulator and dual checkpoint inhibitor, including the NEON-1 study of davoceticept as monotherapy.
    [Alpine Immune Sciences, Inc.]

    Press Release

    IMJUDO® (Tremelimumab) in Combinationq with IMFINZI® (Durvalumab) Approved in the US for Patients with Unresectable Liver Cancer

    AstraZeneca’s Imjudo in combination with Imfinzi has been approved in the US for the treatment of adult patients with unresectable hepatocellular carcinoma, the most common type of liver cancer.
    [AstraZeneca’s IMJUDO®]

    Press Release

    FEATURED EVENT

    Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies

    January 22 – 25, 2022
    Santa Fe, New Mexico, United States

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    JOB OPPORTUNITIES

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    AstraZeneca – Gaithersburg, Maryland, United States

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    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

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    University College London – London, England, United Kingdom

    PhD Student Positions – Tumor Ecosystem

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    Postdoctoral Associate – Immunobiology of Blood Diseases

    Baylor College of Medicine – Houston, Texas, United States

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