Human Immunology News Volume 10.43 | Nov 1 2022

November 1, 2022

2022-11-01 | HIN 10.43

Human Immunology News by STEMCELL Technologies

Vol. 10.43 – 1 November, 2022

TOP STORY

Multi-Omic Analyses of Changes in the Tumor Microenvironment of Pancreatic Adenocarcinoma Following Neoadjuvant Treatment with Anti-PD-1 Therapy

Investigators showed that granulocyte-macrophage colony-stimulating factor-secreting allogeneic pancreatic ductal adenocarcinoma vaccine (GVAX)-induced tertiary lymphoid aggregates became immune-regulatory sites in response to GVAX + nivolumab.
[Cancer Cell]

Full Article Graphical Abstract

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Autoantibody-Mediated Macrophage Dysfunction in Severe Asthma Patients with Airway Infections

Anti-eosinophil peroxidase, anti-macrophage receptor with collagenous structure immunoglobulin G titers, and type 1/2 cytokines were measured in 221 sputa from 143 well-characterized patients with severe asthma.
[American Journal of Respiratory and Critical Care Medicine]

Abstract

BRCA Mutational Status Shapes the Stromal Microenvironment of Pancreatic Cancer Linking Clusterin Expression in Cancer Associated Fibroblasts with HSF1 Signaling

Scientists dissected the stromal landscape of BRCA-mutated and BRCA Wild-type pancreatic ductal adenocarcinoma.
[Nature Communications]

Full Article

Platelet-Derived TLT-1 Promotes Tumor Progression by Suppressing CD8⁺ T Cells

The increased platelet TREM-like transcript 1 (TLT-1) was evident in humanized mice with patient-derived tumors. In immunocompetent mice with syngeneic tumors, TLT-1 binding to T cells, in vivo, led to suppression of CD8 T cells, promoting tumor growth.
[Journal of Experimental Medicine]

Full Article Graphical Absract

Cetuximab Responses in HNSCC Patients Correlate to Clonal Expansion Feature of Peripheral and Tumor-Infiltrating T Cells with Top T Cell Receptor (TCR) Clonotypes

Investigators analyzed high-throughput T cell receptor b sequencing data generated with ImmunoSEQ platform using peripheral blood and tumor infiltrating lymphocytes fromhead and neck squamous cell carcinoma patients before and after cetuximab treatment.
[Clinical Cancer Research]

Abstract

Up-Regulation of BTN3A1 on CD14⁺ Cells Promotes Vγ9Vδ2 T Cell Activation in Psoriasis

The authors showed that circulating Vγ9Vδ2 T cells were decreased and exhibited enhanced proliferation and increased production of IFN-γ and TNF-α in psoriasis vulgaris patients.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Mapping Secretome-Mediated Interaction between Paired Neuron–Macrophage Single Cells

Researchers realized the mapping of 12 different secretomes, covering cytokines, neurotrophic factors, and neuron-derived exosomes from high-throughput, paired single cells (≥ 600) simultaneously under normal conditions and an Alzheimer’s disease model induced with amyloid beta protein 1-42.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Neutrophil Degranulation and Severely Impaired Extracellular Trap Formation at the Basis of Susceptibility to Infections of Hemodialysis Patients

Protein levels and transcriptome of HD patients’ neutrophils indicated massive neutrophil degranulation with a dramatic reduction in reactive oxygen species production during an oxidative burst and defective oxidative cellular signaling.
[BMC Medicine]

Full Article

SIRPα Antibody Combined with Oncolytic Virus OH2 Protects against Tumours by Activating Innate Immunity and Reprogramming the Tumour Immune Microenvironment

Scientists verified the polarization and activation of OH2 in RAW264.7 cells in vitro. Subsequently, they evaluated the antitumour ability of OH2 and anti-SIRPα combined therapy in a tumour-bearing mouse model.
[BMC Medicine]

Full Article

A Cross-Sectional Study Evidences Regulations of Leukocytes in the Colostrum of Mothers with Obesity

Researchers collected peripheral blood and colostrum paired samples from obese and lean mothers within 48 hour post-partum and applied a panel of six antibodies plus a viability marker to characterize 10 major leukocyte subpopulations using flow cytometry.
[BMC Medicine]

Full Article

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REVIEWS

Clinical and Translational Advances in Glioma Immunotherapy

Investigators review recent clinical and translational advances in glioma immunotherapy with a focus on targets and their cognate immune receptor derivates as well as concepts to improve intratumoral T cell effector functions.
[Neurotherapeutics]

Full Article

B Cell Phenotype, Activity, and Function in Idiopathic Nephrotic Syndrome

Scientists provide a detailed description of the current knowledge on the development, differentiation, activity, functions, and related regulating factors of B cells involved in idiopathic nephrotic syndrome.
[Pediatric Research]

Abstract

INDUSTRY AND POLICY NEWS

2seventy bio and JW Therapeutics Announce Strategic Partnership to Accelerate the Research and Development of T Cell-Based Immunotherapies

2seventy bio, Inc. and JW Therapeutics announced a strategic alliance to establish a translational and clinical cell therapy development platform designed to more rapidly explore T cell-based immunotherapy therapy products in the Chinese mainland, Hong Kong, and Macao.
[2seventy bio, Inc.]

Press Release

Teon Therapeutics Announces First Patient Treated in Phase I/II Clinical Trial of TT-816, a Novel Oral Immune Checkpoint Inhibitor, in Patients with Advanced Solid Tumors

Teon Therapeutics announced that the first patient has been treated in its Phase I/II clinical trial evaluating the safety and efficacy of TT-816, an oral CB2 receptor antagonist acting as an immune checkpoint inhibitor while promoting T cell infiltration of cold tumors and stimulating NK cell tumor killing.
[Teon Therapeutics]

Full Article

FEATURED EVENT

Human Immunology News Volume 10.43 | Nov 1 2022

Multi-Omic Analyses of Changes in the Tumor Microenvironment of Pancreatic Adenocarcinoma Following Neoadjuvant Treatment with Anti-PD-1 Therapy

Autoantibody-Mediated Macrophage Dysfunction in Severe Asthma Patients with Airway Infections

BRCA Mutational Status Shapes the Stromal Microenvironment of Pancreatic Cancer Linking Clusterin Expression in Cancer Associated Fibroblasts with HSF1 Signaling

Platelet-Derived TLT-1 Promotes Tumor Progression by Suppressing CD8⁺ T Cells

Cetuximab Responses in HNSCC Patients Correlate to Clonal Expansion Feature of Peripheral and Tumor-Infiltrating T Cells with Top T Cell Receptor (TCR) Clonotypes

Up-Regulation of BTN3A1 on CD14⁺ Cells Promotes Vγ9Vδ2 T Cell Activation in Psoriasis

Mapping Secretome-Mediated Interaction between Paired Neuron–Macrophage Single Cells

Neutrophil Degranulation and Severely Impaired Extracellular Trap Formation at the Basis of Susceptibility to Infections of Hemodialysis Patients

SIRPα Antibody Combined with Oncolytic Virus OH2 Protects against Tumours by Activating Innate Immunity and Reprogramming the Tumour Immune Microenvironment

A Cross-Sectional Study Evidences Regulations of Leukocytes in the Colostrum of Mothers with Obesity

Clinical and Translational Advances in Glioma Immunotherapy

B Cell Phenotype, Activity, and Function in Idiopathic Nephrotic Syndrome

2seventy bio and JW Therapeutics Announce Strategic Partnership to Accelerate the Research and Development of T Cell-Based Immunotherapies

Teon Therapeutics Announces First Patient Treated in Phase I/II Clinical Trial of TT-816, a Novel Oral Immune Checkpoint Inhibitor, in Patients with Advanced Solid Tumors

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