Human Immunology News Volume 10.44 | Nov 8 2022

November 8, 2022

2022-11-08 | HIN 10.44

Human Immunology News by STEMCELL Technologies

Vol. 10.44 – 8 November, 2022

TOP STORY

Targeting Cancer Glycosylation Repolarizes Tumor-Associated Macrophages Allowing Effective Immune Checkpoint Blockade

Investigators showed that tumor sialylation correlates with distinct immune states and reduced survival in human cancers.
[Science Translational Medicine]

Abstract Press Release

Win an award toward an upcoming cell or gene therapy conference

PUBLICATIONSRanked by the impact factor of the journal

IgA⁺ Memory B Cells Are Significantly Increased in Patients with Asthma and Small Airway Dysfunction

In the All Age Asthma Cohort, a subgroup of 154 adult asthma patients and 28 healthy controls were included for B cell characterisation by flow cytometry.
[European Respiratory Journal]

Abstract

JAK2V617F Mutation Drives Vascular Resident Macrophages toward a Pathogenic Phenotype and Promotes Dissecting Aortic Aneurysm

Using single-cell RNA-seq and complementary genetically-modified mouse models, investigators found that JAK2V617F mutation was associated with a pathogenic pro-inflammatory phenotype of perivascular tissue-resident macrophages, which promoted deleterious aortic wall remodeling at early stages
[Nature Communications]

Full Article

T Cell Responses at Diagnosis of Amyotrophic Lateral Sclerosis Predict Disease Progression

The authors showed, by flow cytometric analysis of blood and cerebrospinal fluid samples of a cohort of 89 newly diagnosed amyotrophic lateral sclerosis patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis were good predictors of disease outcome.
[Nature Communications]

Full Article

Blocking STAT3/5 through Direct or Upstream Kinase Targeting in Leukemic Cutaneous T Cell Lymphoma

Scientists integrated genomic landscape analyses with innovative pharmacologic interference studies to identify key vulnerable nodes in leukemic cutaneous T cell lymphomas.
[EMBO Molecular Medicine]

Full Article

Isolating and Targeting a Highly Active, Stochastic Dendritic Cell Subpopulation for Improved Immune Responses

Researchers isolated a unique dendritic subpopulation via preferential phagocytosis of microparticles and characterized this subpopulation of “first responders”.
[Cell Reports]

Full Article Graphical Abstract

PA-MSHA Induces Inflamed Tumor Microenvironment and Sensitizes Tumor to Anti-PD-1 Therapy

The effect of Pseudomonas aeruginosa mannose-sensitive-hemagglutinin in facilitating T cell activation was determined in vitro and in vivo.
[Cell Death & Disease]

Full Article

Expression and Regulatory Characteristics of Peripheral Blood Immune Cells in Primary Sjögren’s Syndrome Patients Using Single-Cell Transcriptomics

Investigators performed single-cell RNA sequencing of about 68,500 peripheral blood mononuclear cells from three patients with Primary Sjogren’s syndrome and three healthy controls.
[iScience]

Abstract Full Article Graphical Abstract

Single-Cell RNA Sequencing Reveals Rebalancing of Immunological Response in Patients with Periodontitis after Non-Surgical Periodontal Therapy

The authors profiled peripheral blood mononuclear cell from healthy controls and paired pre- and post-treatment patients with periodontitis. They extracted differentially expressed genes and biological pathways for each cell type and calculated activity scores reflecting cellular characteristics.
[Journal of Translational Medicine]

Full Article

Characteristics of Circulating Adaptive Immune Cells in Patients with Colorectal Cancer

The number, phenotype, and function of different subsets of circulating adaptive immune cells in peripheral blood of colorectal cancer patients were analyzed.
[Scientific Reports]

Full Article Press Release

Endothelial Dysfunction Markers and Immune Response Indices in Cosmonauts’ Blood after Long-Duration Space Flights

Scientists investigated the markers of endothelial activation and damage, von Willebrand factor, highly sensitive C-reactive protein, as well as the level of D-dimer and compared them to the immunological parameters characterizing the state of human humoral and cellular immunity.
[NPJ Microgravity]

Full Article

Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.

REVIEWS

Emerging Roles of Innate and Adaptive Immunity in Alzheimer’s Disease

The authors review the roles of innate and adaptive immunity, their niches, their communication, and their contributions to Alzheimer’s disease development and progression.
[Immunity]

Abstract

Neuronal Regulation of B Cell Immunity: Anticipatory Immune Posturing?

Scientists provide a synthesis of studies pertinent to neuronal regulation of B cell responses in secondary lymphoid organs.
[Neuron]

Full Article

INDUSTRY AND POLICY NEWS

DynamiCure Doses First Patients in Phase I Clinical Trial of Lead Antibody Candidate DCBY02 in Advanced Cancers

DynamiCure announced that it has dosed the first patients in its Phase I clinical trial evaluating the safety and anti-tumor activity of the first of the company’s two anti-CD93 monoclonal antibody candidates, DCBY02, in adults with a wide range of advanced cancers.
[DynamiCure]

Press Release

Immunomic Therapeutics Receives FDA Fast Track Designation for ITI-3000, a pDNA Vaccine, in Development for the Treatment of Merkel Cell Carcinoma

Immunomic Therapeutics, Inc. announced that the FDA has granted Fast Track Designation to the ITI-3000 program for the treatment of patients with Merkel cell carcinoma.
[Immunomic Therapeutics, Inc]

Press Release

FEATURED EVENT

Human Immunology News Volume 10.44 | Nov 8 2022

Targeting Cancer Glycosylation Repolarizes Tumor-Associated Macrophages Allowing Effective Immune Checkpoint Blockade

IgA⁺ Memory B Cells Are Significantly Increased in Patients with Asthma and Small Airway Dysfunction

JAK2V617F Mutation Drives Vascular Resident Macrophages toward a Pathogenic Phenotype and Promotes Dissecting Aortic Aneurysm

T Cell Responses at Diagnosis of Amyotrophic Lateral Sclerosis Predict Disease Progression

Blocking STAT3/5 through Direct or Upstream Kinase Targeting in Leukemic Cutaneous T Cell Lymphoma

Isolating and Targeting a Highly Active, Stochastic Dendritic Cell Subpopulation for Improved Immune Responses

PA-MSHA Induces Inflamed Tumor Microenvironment and Sensitizes Tumor to Anti-PD-1 Therapy

Expression and Regulatory Characteristics of Peripheral Blood Immune Cells in Primary Sjögren’s Syndrome Patients Using Single-Cell Transcriptomics

Single-Cell RNA Sequencing Reveals Rebalancing of Immunological Response in Patients with Periodontitis after Non-Surgical Periodontal Therapy

Characteristics of Circulating Adaptive Immune Cells in Patients with Colorectal Cancer

Endothelial Dysfunction Markers and Immune Response Indices in Cosmonauts’ Blood after Long-Duration Space Flights

Emerging Roles of Innate and Adaptive Immunity in Alzheimer’s Disease

Neuronal Regulation of B Cell Immunity: Anticipatory Immune Posturing?

DynamiCure Doses First Patients in Phase I Clinical Trial of Lead Antibody Candidate DCBY02 in Advanced Cancers

Immunomic Therapeutics Receives FDA Fast Track Designation for ITI-3000, a pDNA Vaccine, in Development for the Treatment of Merkel Cell Carcinoma

Type 2 Immunity in Homeostasis and Disease (2nd Edition)

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Postdoctoral Fellow – Molecular Immunology

Laboratory Technician – Immune System and Chronic Respiratory Diseases

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Research Fellow – T Cell Engineering and Immunotherapy

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