Human Immunology News Volume 10.45 | Nov 15 2022

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    Laurisa Dohm
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    2022-11-15 | HIN 10.45


    Human Immunology News by STEMCELL Technologies
    Vol. 10.45 – 15 November, 2022
    TOP STORY

    Liver Tumor Immune Microenvironment Subtypes and Neutrophil Heterogeneity

    Scientists performed single-cell RNA-sequencing analysis of 189 samples collected from 124 patients and eight mice with liver cancer.
    [Nature]

    Full Article
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    Enhanced T Cell Effector Activity by Targeting the Mediator Kinase Module

    Researchers used genome-wide CRISPR knockout screens in human T cells to identify regulators of T cell fitness.
    [Science]

    Abstract

    The Transcription Factor IRF2 Drives Interferon-Mediated CD8+ T Cell Exhaustion to Restrict Anti-Tumor Immunity

    Researchers demonstrated that the transcription factor interferon regulatory factor 2 (IRF2) was expressed by many immune cells in the tumor in response to sustained IFN signaling.
    [Immunity]

    AbstractGraphical Abstract

    Lysophosphatidylcholines Modulate Immunoregulatory Checkpoints in Peripheral Monocytes and Are Associated with Mortality in People with Acute Liver Failure

    Investigators describe the metabolic dysregulation in acute liver failure and determine whether systemic immune responses are modulated via the lysophosphatidylcholine-autotaxin-lysophosphatidylcholinic acid pathway.
    [Journal of Hepatology]

    Full ArticleGraphical Abstract

    Blockade of the Immunosuppressive KIR2DL5/PVR Pathway Elicits Potent Human NK Cell–Mediated Antitumor Immunity

    The authors reported that KIR2DL5 was predominantly expressed on human NK cells with mature phenotype and cytolytic function and that it bound to PVR without competition with the other three known PVR receptors.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Pooled Screening of CAR T Cells Identifies Diverse Immune Signaling Domains for Next-Generation Immunotherapies

    Forty CARs with signaling domains derived from a range of immune cell lineages were evaluated in pooled assays for their ability to stimulate critical T cell effector functions during repetitive stimulation that mimics long-term tumor antigen exposure.
    [Science Translational Medicine]

    Full ArticlePress Release

    T-Cell and Cytokine Dynamics in the Blood of Patients After Hematopoietic Stem Cell Transplantation and Multipotent Mesenchymal Stromal Cells Administration

    After allogeneic hematopoietic stem cell transplantation, patients were randomized into two groups: the one receiving standard graft-versus-host disease prophylaxis, and another one receiving additionally mesenchymal stromal cells infusion on the day of recovery of leukocytes to 1000 cells/μl.
    [Transplantation and Cellular Therapy]

    Abstract

    Expansions of Tumor-Reactive Vdelta1 Gamma-Delta T Cells in Newly Diagnosed Patients with Chronic Myeloid Leukemia

    Investigators analyzed Vδ1 and Vδ2 γδ T cell subsets in newly diagnosed chronic myeloid leukemia patients who had initiated tyrosine kinase inhibitor therapy including imatinib, nilotinib, and dasatinib.
    [Cancer Immunology Immunotherapy]

    Full Article

    Pro- and Anti-Inflammatory Cytokines Interleukin-6 and Interleukin-10 Predict Therapy Outcome of Female Patients with Posttraumatic Stress Disorder

    Pro-and anti-inflammatory cytokines in female PTSD patients were assessed under acute stress during a Trier social stress test before therapeutic treatment.
    [Translational Psychiatry]

    Full Article

    Adenosine Signaling in T-Cell Activation Favors Development of IL-17 Positive Cells with Suppressive Properties

    Proliferation, phenotype and cytokine production of stimulated T cells were assessed by flow cytometry, multiplex assay, and ELISA. Gene expression profiling was determined by microarray.
    [Immunology]

    Abstract
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    REVIEWS

    Immune Cell Dysregulation as a Mediator of Fibrosis in Systemic Sclerosis

    Investigators summarize the most pertinent findings concerning the involvement of dysregulated immune responses in fibrosis of the skin and lungs in systemic sclerosis (SSc) and highlight the current and potential immune-based targets for SSc therapeutics.
    [Nature Reviews Rheumatology]

    Abstract

    Weaponizing Natural Killer Cells for Solid Cancer Immunotherapy

    The authors summarize and discuss recent advances in the field and highlight current and potential future use of immunotherapies to maximize the therapeutic efficacy of innate anticancer immunity.
    [Trends in Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Kyverna Therapeutics Announces FDA Clearance of IND for KYV-101, a Novel Fully Human CD19 CAR T-Cell Therapy to Treat Lupus Nephritis

    Kyverna Therapeutics announced the clearance of its first Investigational New Drug (IND) application by the FDA to initiate a Phase I clinical trial of KYV-101, a novel therapy for the treatment of lupus nephritis.
    [Kyverna Therapeutics]

    Press Release

    Carl H. June Awarded the Inaugural Maria I. New International Prize for Biomedical Research

    Carl H. June, MD, an inventor of CAR T cell therapy for cancer was awarded the inaugural Maria I. New International Prize for Biomedical Research at the Icahn School of Medicine at Mount Sinai.
    [Mount Sinai Health System]

    Press Release
    FEATURED EVENT

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    December 4 – 7, 2022
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    JOB OPPORTUNITIES

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

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    University of Toronto Mississauga – Mississauga, Ontario, Canada

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    AstraZeneca – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cardiac Inflammation

    Lund University – Lund, Sweden

    Postdoctoral Fellow – Molecular Immunology

    Universit̩ Libre de Bruxelles РGosselies, Belgium

    > See All Jobs

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