Human Immunology News Volume 10.46 | Nov 22 2022

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    Laurisa Dohm
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    2022-11-22 | HIN 10.46


    Human Immunology News by STEMCELL Technologies
    Vol. 10.46 – 22 November, 2022
    TOP STORY

    How We Diagnose and Treat Acute Graft-versus-Host Disease after Solid Organ Transplantation

    Signs and symptoms of graft-versus-host disease (GVHD) following solid organ transplantation were nonspecific and include a rash, nausea, appetite loss, diarrhea, and cytopenias. Pancytopenia from marrow-directed GVHD was the primary driver of mortality.
    [Blood]

    Abstract
    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    PUBLICATIONSRanked by the impact factor of the journal

    A Polyamine-Centric, Blood-Based Metabolite Panel Predictive of Poor Response to CAR-T Cell Therapy in Large B Cell Lymphoma

    Researchers tested whether an MYC-driven polyamine signature, as a liquid biopsy, was predictive of response to anti-CD19 CAR-T therapy in patients with relapsed or refractory large B cell lymphoma.
    [Cell Reports Medicine]

    Full Article

    BCG Vaccinations Drive Epigenetic Changes to the Human T Cell Receptor: Restored Expression in Type 1 Diabetes

    Scientists investigated the mechanisms behind the autoimmune benefits and tested the hypothesis that a microbe synergy could be due to an impact on the host T cell receptor and T cell receptor signal strength.
    [Science Advances]

    Full Article

    Somatic 9p24.1 Alterations in HPV– Head and Neck Squamous Cancer Dictate Immune Microenvironment and Anti-PD-1 Checkpoint Inhibitor Activity

    Investigators reported multi-omic, -threshold and continuous-variable dissection of 9p21 and 9p24 loci and tumor microenvironment of four human papillomavirus–negative head and neck squamous cancer cohorts.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    CD8+ T Cell Metabolic Rewiring Defined by scRNA-Seq Identifies a Critical Role of ASNS Expression Dynamics in T Cell Differentiation

    Researchers identified a differential time-dependent reliance of activating T cells on the synthesis versus uptake of various non-essential amino acids, which they corroborated with functional assays.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Nuclease-Independent Functions of RAG1 Direct Distinct DNA Damage Responses in B Cells

    To delineate the factors that direct DDR signaling in B cells, scientists expressed a tetracycline-inducible Cas9 nuclease in Rag1-deficient pre-B cells.
    [EMBO Reports]

    AbstractGraphical Abstract

    Single-Cell Analyses Reveal Novel Molecular Signatures and Pathogenesis in Cutaneous T Cell Lymphoma

    The authors performed a comprehensive analysis by integrating single-cell transcriptomic data of 40,333 peripheral blood mononuclear cells (PBMCs) and 41,580 skin cells, as well as single-cell chromatin accessibility data of 11,058 PBMCs from an Sézary syndrome patient and matched healthy controls.
    [Cell Death & Disease]

    Full Article

    Epigenome-Wide Analysis of T Cell Large Granular Lymphocytic Leukemia Identifies BCL11B as a Potential Biomarker

    For identification of molecular events driving the pathogenesis of T cell large granular lymphocytic leukemia (T-LGLL), researchers compared the differentially methylated loci between the T-LGLL cases and normal T cells with chromatin segmentation data of benign T cells.
    [Clinical Epigenetics]

    Full Article

    Microfluidic Live Tracking and Transcriptomics of Cancer-Immune Cell Doublets Link Intercellular Proximity and Gene Regulation

    Scientists tracked the temporal variations in natural killer—triple-negative breast cancer cell distances and compareed them with terminal cellular transcriptome profiles.
    [Communications Biology]

    Full Article
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    TGFβ Control of Immune Responses in Cancer: A Holistic Immuno-Oncology Perspective

    Investigators discuss the contextual complexity of transforming growth factor-β (TGFβ) signaling in tumor-elicited immune responses and explain how understanding this may guide the development of mechanism-based cancer immunotherapy
    [Nature Reviews Immunology]

    Abstract

    Macrophages in Health and Disease

    The authors propose that the ontogeny of a macrophage constitutes a critical piece of information about its contribution to homeostasis or the progression of disease.
    [Cell]

    Full Article
    INDUSTRY AND POLICY NEWS

    Genmab Announces US Food and Drug Administration Accepts for Priority Review Biologics License Application (BLA) for Epcoritamab (DuoBody®-CD3xCD20) for the Treatment of Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

    Genmab A/S announced that the FDA has accepted for Priority Review the Biologics License Application for subcutaneous epcoritamab, an investigational bispecific antibody, for the treatment of patients with relapsed/refractory large B cell lymphoma after two or more lines of systemic therapy.
    [Genmab A/S]

    Press Release

    Boosted by $3 Million in Seed Funding, Queen Mary Spin-Out Heralds Developments in Cancer Immunotherapies and a Vision of Immune System Stimulation

    VacV Biotherapeutics, a cancer immunotherapy company and Queen Mary spin-out developing innovative viral-based therapies, has advanced its promising pipeline of pre-clinical treatments after strong testing results thus far.
    [Queen Mary University of London]

    Press Release
    FEATURED EVENT

    Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies

    January 22 – 25, 2023
    Santa Fe, New Mexico, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Human Intestinal Biology

    Baylor College of Medicine – Houston, Texas, United States

    PhD positions – EuReCa PhD Program

    Institut Curie – Paris, France

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

    Assistant Professor – Immunology

    University of Toronto Mississauga – Mississauga, Ontario, Canada

    Postdoctoral Fellow – Cardiac Inflammation

    Lund University – Lund, Sweden

    > See All Jobs

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