 | | Vol. 10.47 – 6 December, 2022 |
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| In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11–93 years, scientists found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Ten patients were treated with 36–165 x 106 CART19/20 cells. No patient experienced neurotoxicity of any grade, or over grade-1 cytokine release syndrome. One case of dose-limiting toxicity was observed.
[Cancer Discovery] |
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| In Treg cells, a CRISPR-Cas9–enabled Pfkp deletion recapitulated the metabolism of Camk4−/− Treg cells, and improved their function and stability in vitro and in vivo.
[Science Advances] |
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| Scientitsts curated 1275 immune-related genes and investigated their expression changes in 2467 postmortem brains of controls and patients with six major brain disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, major depressive disorder, Alzheimer’s disease, and Parkinson’s disease.
[Molecular Psychiatry] |
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| Researchers examined the effects of interval administration of low-dose recombinant IL-2 in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples.
[Nature Communications] |
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| Early microbial exposure resulted in the preferential expansion of highly responsive fetal-derived CD8+ T cells that persist into adulthood and provide the host with enhanced immune protection against intracellular pathogens.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers assessed the structural diversity and clonal repertoire of IgA1-containing molecular assemblies longitudinally in human serum and milk from three donors using a mass spectrometry-based approach.
[Cellular & Molecular Immunology] |
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| Mechanistically, T cell immunoglobulin and mucin domain-containing molecule 4 (Tim-4) disturbed the Insig1-SCAP interaction and promoted SCAP-SREBP2 complex translocation to the Golgi apparatus.
[Cell Reports] |
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| Scientists summarize current clinical evidence of off-tumor toxicity (OTOT) with CAR T cells in the treatment of solid tumors and discuss the utility of preclinical mouse models in predicting clinical OTOT.
[Nature Reviews Clinical Oncology] |
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| The author summarizes the journey of the past 25 years that has led to the successful use of gene therapy for Inborn errors of immunity and discusses the next steps for the field.
[Nature Reviews Immunology] |
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| The two companies have entered into a multi-target research collaboration for several small molecule immunotherapy programs as well as an exclusive license agreement for Ryvu’s STING agonist portfolio as standalone small molecules.
[BioNTech and Ryvu Therapeutics] |
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| The FDA granted Investigational New Drug (IND) clearances of PYX-201, a novel antibody-drug conjugate product candidate, and PYX-106, an immunotherapy product candidate.
[Pyxis Oncology, Inc.] |
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| January 29 – February 2, 2023
Banff, Alberta, Canada |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | Bristol Myers Squibb – Uxbridge, England, United Kingdom |
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| | The Ottawa Hospital – Ottawa, Ontario, Canada |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | AstraZeneca – Gothenburg, Sweden OR Gaithersburg or Wilmington, United States |
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