 | | Vol. 11.01 – 10 January, 2023 |
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| In the immune checkpoint inhibitor in combination with nab-paclitaxel cohort, tumor samples from responders showed significant distribution of PD-L1 at mitochondria, while non-responders instead showed increased accumulation of PD-L1 on tumor cell membrane.
[Cell Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that human T cells expressed gasdermin E and that this expression was associated with durable viability and repurposed for the release of the alarmin interleukin (IL)-1α.
[Nature Immunology] |
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| The authors developed a method to identify peptide-major histocompatibility complex (pMHC) whose structural alignment facilitates T cell reaction. This method predicted neoepitopes for MHC II and MHC I that were responsive to checkpoint blockade when applied to >1,200 samples of various tumor types.
[Nature Genetics] |
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| Researchers conducted a multicenter, dose-escalation, phase I trial in patients with relapsed/refractory metastatic solid tumors expressing MAGE-A4, including synovial sarcoma, ovarian cancer and head and neck cancer.
[Nature Medicine] |
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| The authors classified the tumor microenvironment (TME) by analyzing the transcriptome from 11,069 cancer patients based on angiogenesis and T cell activity, and found three distinct angio-immune TME subtypes conserved across 30 non-hematological cancers.
[Cell Reports Medicine] |
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| Using single-cell transcriptomics combined with imaging mass cytometry, scientists systematically studied immune environments of human breast tumors that either did or did not contain exhausted T cells, with a focus on luminal subtypes.
[Nature Communications] |
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| Researchers identified TRIM21 as an E3 ligase that governs CD73 destruction. Disruption of TRIM21 stabilized CD73, that in turn enhanced CD73-catalyzed production of adenosine, resulting in the suppression of CD8+ T cell function.
[Science Advances] |
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| Investigators utilized single-cell RNA sequencing and whole-exome sequencing data of glioblastoma tissues and identified a subset of tumor-associated macrophages dually expressing macrophage and tumor signatures.
[Cancer Research] |
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| Results using hepatocellular carcinoma patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1, a kynurenine producing enzyme with effects on tumor immune escape, and Lin28B.
[Molecular Therapy] |
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| Investigators present representative examples about the latest advances of biomaterial-based delivery systems employed in cancer immunotherapy, including immune cells, bacteria, and their derivatives.
[Acs Nano] |
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| The authors summarize the evolving literature regarding these Gata6+ large peritoneal macrophages, focusing on ontogeny, their responses to perturbations, including their rapid aggregation via coagulation, as well as scavenger receptor cysteine-rich domains and their potential roles in diseases, such as cancer.
[Trends In Immunology] |
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| Scientists illustrate the mechanisms of bacteria as both efficient tumor immunogenic cell death inducers, and tumor-targeted delivery platforms. They then review the engineering strategies for designing bacteria-based in situ vaccination, including chemical modification, nanotechnology, and genetic engineering.
[Biomaterials Science] |
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| The initial Phase I clinical trial will assess safety and therapeutic benefit from the administration of Phio’s PH-762 treated “double positive” CD8 tumor infiltrating lymphocyte in patients with melanoma and other advanced solid tumors.
[Phio Pharmaceuticals Corp.] |
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| Instil Bio, Inc. announced the resumption of its Phase I clinical trial of ITIL-306 for the treatment of non-small cell lung cancer, ovarian cancer, and renal cell carcinoma.
[Instil Bio, Inc.] |
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| February 15 – 17, 2023
Lorne, Victoria, Australia |
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| | Shanghai Clinical Research and Trial Center – Shanghai, China |
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| | STEMCELL Technologies РSt. Egreve, Auvergne-Rh̫ne-Alpes, France |
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| | Rutgers New Jersey Medical School – Newark, New York, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Pfizer – Pearl River, New York, United States |
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