Immunology of Infectious Disease News Volume 11.02 | Jan 18 2023

    By
    Laurisa Dohm
    -
    0
    21








    2023-01-18 | IIDN 11.02


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.02 – 18 January, 2023
    TOP STORY

    Dome1–JAK–STAT Signaling between Parasite and Host Integrates Vector Immunity and Development

    The authors report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma.
    [Science]

    AbstractPress ReleaseGraphical Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Z-RNA Activates the ZBP1-RIPK3 Pathway to Promote Virus-Induced Inflammatory Responses

    Researchers report that SARS-CoV-2 infection resulted in the formation of viral “Z-form” RNA (Z-RNA) in the cytoplasm of infected cells and thereby activated the ZBP1-RIPK3 pathway.
    [Cell Research]

    Full Article

    Rapidly Shifting Immunologic Landscape and Severity of SARS-CoV-2 in the Omicron Era in South Africa

    Scientists analyzed sequential serum samples collected through a prospective cohort study before, during, and after the Omicron BA.1/2 wave to infer infection rates and monitor changes in the immune histories of participants over time.
    [Nature Communications]

    Full Article

    Ablation of Adar1 in Myeloid Cells Imprints a Global Antiviral State in the Lung and Heightens Early Immunity against SARS-CoV-2

    Investigators showed that ADAR1 deletion in CD11c+ antigen presenting cells lead to a skewed myeloid cell compartment enriched in inflammatory cDC2-like cells, enhanced numbers of activated tissue resident memory T cells in the lung, the imprinting of a broad antiviral transcriptional signature across both immune and non-immune cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    A Two-Gene Marker for the Two-Tiered Innate Immune Response in COVID-19 Patients

    The activation patterns of this two-tiered innate immune response represented by IFI27 and S100A12 were explored based on 1421 samples from 17 transcriptome datasets derived from the blood of COVID-19 patients and relevant controls.
    [Plos One]

    Full Article

    Impaired CD4+ T Cell Response in Older Adults Is Associated with Reduced Immunogenicity and Reactogenicity of mRNA COVID-19 Vaccination

    Using a vaccinated cohort, researchers demonstrated that adults ≥65 years had fewer vaccine-induced spike-specific CD4+ T cells, including CXCR3+ circulating follicular helper T cells, and the TH1 subset of helper T cells after the first dose.
    [Nature Aging]

    Full Article

    Safety and Immunogenicity of a Monovalent Inactivated Influenza A/H5N8 Virus Vaccine Given with and without AS03 or MF59 Adjuvants in Healthy Adults

    275 healthy adults, ages 19-64 years, were randomized to one of five groups to receive two doses of 15 µg unadjuvanted influenza A /H5N8 virus vaccine, or two doses of 7.5 or 15 µg of vaccine adjuvanted with AS03 or MF59.
    [Clinical Infectious Diseases]

    Abstract

    New Insight into Epstein-Barr Virus Infection Using Models of Stratified Epithelium

    Given that infected epithelial cells and cell-free Epstein-Barr virus were observed in saliva, researchers examined the ability of both of these to mediate infection in organotypic cultures.
    [Plos Pathogens]

    Full Article

    Monkeypox-Associated Central Nervous System Disease: A Case Series and Review

    Three cases of Monkeypox virus-associated central nervous system disease occurring during the 2022 outbreak and their associated imaging findings were presented.
    [Annals Of Neurology]

    Abstract

    Sex and Prior Exposure Jointly Shape Innate Immune Responses to a Live Herpesvirus Vaccine

    Investigators employed systems immunology approaches to study responses to a replication-defective, herpes simplex virus (HSV) 2 vaccine in men and women, either naive or previously exposed to HSV.
    [Elife]

    Full Article
    Take the Immunology Podcast feedback survey for a chance to win a Bluetooth speaker.
    REVIEWS

    Long COVID: Major Findings, Mechanisms, and Recommendations

    The authors explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children, and the impact of vaccinations.
    [Nature Reviews Microbiology]

    Full Article

    Innate Immune Evasion Strategies of SARS-CoV-2

    Investigators examine the relationship between SARS-CoV-2 biology and the cellular response to infection, detailing how antagonism and dysregulation of host innate immune defences contribute to disease severity of COVID-19.
    [Nature Reviews Microbiology]

    Full Article

    Novel Monoclonal Antibody-Based Therapies: Implications for the Treatment and Prevention of HCMV Disease

    Scientists provide a synthesis of recent data, revising the literature supporting, and arguing about the role of humoral immunity in controlling human cytomegalovirus (HCMV) infection.
    [Trends In Microbiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA No Longer Needs to Require Animal Tests before Human Drug Trials

    New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
    [ScienceInsider]

    Press Release
    FEATURED EVENT

    Immuno UK

    March 28 – 29, 2023
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Coronavirus Research

    LMU Munich – Munich, Germany

    Lab Technician – CRISPR-Cas9 in Neuroimmunology

    The University of Luxembourg – Belval, Luxembourg

    Sheila Joan Smith Professorship – Immunology

    University of Cambridge – Cambridge, England, United Kingdom

    Research Chair – Immunology

    The University of Edinburgh – Edinburgh, Scotland, United Kingdom

    European Market Development Manager – Immunology

    STEMCELL Technologies – St. Egreve, France

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immunology of Infectious Disease News Twitter