 | | Vol. 11.02 – 18 January, 2023 |
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| 260 ccRCC samples from three different cohorts consisting of 213 primary tumors and 47 metastases were obtained. We focused on five representative innate immune signatures, CD68, CD163, the “eat me” signal calreticulin, the “don’t eat me” signal CD47, and signal regulatory protein α, and examined the role of each signature by quantitative immunohistochemistry.
[Cancer Immunology Immunotherapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers engineered a trifunctional natural killer cell engager that targeted CD123, the alpha chain of the IL-3 receptor, on acute myeloid leukemia blasts and NKp46 and CD16a on NK cells.
[Nature Biotechnology] |
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| The authors performed an extensive characterization of the immunogenomic landscape of human brain metastases by combining whole-exome/whole-genome sequencing, RNA sequencing of immune cell populations, flow cytometry, immunofluorescence staining, and tissue imaging analyses.
[Cell Reports Medicine] |
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| Single cell transcriptomics revealed that CD4+ T-cell help uniquely optimized cDC1 in many functions that supported antigen cross-presentation and T cell priming, while these changes did not apply to other dendritic cells types.
[Nature Communications] |
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| Investigators showed that, across human and/or mouse tumors, immune dysfunction was associated with cancer cells acquiring epigenetic features of inflammatory memory.
[Nature Cancer] |
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| Scientists investigated whether CAR T cells could be used as an adjuvant therapy to clear residual cancer cells. They tested the feasibility of this approach in two partial resection xenograft models using mesothelin-specific CAR T cells.
[Science Advances] |
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| By combining MHCII allele purification, allele-independent peptide loading, and multiplexed flow cytometry technologies, researchers developed a method that enabled high-throughput personalized CD4+ T cell identification, immunophenotyping, and sorting.
[Cell Reports Methods] |
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| The expression of A disintegrin and metalloprotease 17 in glioma cells was positively correlated with the expression of soluble LRIG3 (sLRIG3) in cell supernatant. sLRIG3 could suppress the M2-like polarity transformation of tumor-associated macrophages and inhibit the growth of tumor.
[Cell Death & Disease] |
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| The authors conducted a small molecule compound library screen in a human breast cancer cell line to identify whether certain drugs contribute to CAR T cell killing. Signaling pathways of tumor cells and T cells affected by the screened drugs were predicted via RNA sequencing.
[Journal Of Translational Medicine] |
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| Scientists describe data on selected novel oncolytic viruses (OVs) that are currently in clinical development, either as monotherapies or as part of combination regimens, as well as some of the preclinical, clinical, and regulatory hurdles that have thus far limited the development of OVs.
[Nature Reviews Clinical Oncology] |
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| The authors discuss recent advances in understanding how T follicular helper cell crosstalk with B cells and CD8+ T cells in secondary and tertiary lymphoid structures enhances antitumor immunity, but may also exacerbate immune-related adverse events related to cancer immunotherapy.
[Trends in Cancer] |
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| TC Biopharm PLC announced a strategic collaboration with The University of Texas MD Anderson Cancer Center to expand the knowledge base of how gamma-delta T cells work in oncology settings.
[TC Biopharm PLC] |
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| Jennifer Wargo received a 2023 Edith and Peter O’Donnell Award in Medicine from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) for her contributions to the understanding of how the gut microbiome influences responses to immunotherapy and other cancer treatments.
[MD Anderson Cancer Center] |
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| March 19 – 21, 2023
Sitges, Spain |
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| | Bar-Ilan University – Ramat Gan, Israel |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | STEMCELL Technologies – St. Egreve, France |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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