Human Immunology News Volume 11.03 | Jan 24 2023

    By
    Laurisa Dohm
    -
    0
    82








    2023-01-24 | HIN 11.03


    Human Immunology News by STEMCELL Technologies
    Vol. 11.03 – 24 January, 2023
    TOP STORY

    BTG1 Mutation Yields Supercompetitive B Cells Primed for Malignant Transformation

    By studying primary human lymphomas and developing new mouse models, scientists found that mutations affecting B cell translocation gene 1 (BTG1) disrupted a critical immune gatekeeper mechanism that strictly limited B cell fitness during antibody affinity maturation.
    [Science]

    AbstractPress Release
    Request a copy of the COVID-19 wallchart.
    PUBLICATIONSRanked by the impact factor of the journal

    Tissue Adaptation and Clonal Segregation of Human Memory T Cells in Barrier Sites

    Investigators obtained blood and tissues from human organ donors to examine T cells across major barrier sites including skin, lung, and jejunum, associated lymph nodes, lymphoid organs including spleen, bone marrow, and in circulation.
    [Nature Immunology]

    Full Article

    Immunotherapy-Induced Neutralizing Antibodies Disrupt Allergen Binding and Sustain Allergen Tolerance in Peanut Allergy

    The authors compared antibodies from individuals with sustained or transient allergic responses, and discovered specific tolerance-associated conformational epitopes of the immunodominant allergen Ara h 2 recognized by neutralizing antibodies.
    [Journal Of Clinical Investigation]

    Full ArticleGraphical Abstract

    Integrated Single-Cell Profiling Dissects Cell-State-Specific Enhancer Landscapes of Human Tumor-Infiltrating CD8+ T Cells

    Researchers identified gene-regulatory landscapes in a wide breadth of functional and dysfunctional CD8+ tumor-infiltrating lymphocyte states, covering four cancer entities using single-cell chromatin profiling.
    [Molecular Cell]

    Full ArticleGraphical Abstract

    Cytotoxic CD8+ T Cells Target Citrullinated Antigens in Rheumatoid Arthritis

    Investigators performed single cell transcriptome and T cell receptor sequencing of CD8+ T cells derived from anti-citrullinated protein antibodies + rheumatoid arthritis blood samples.
    [Nature Communications]

    Full Article

    PD-1 Blockade and CDK4/6 Inhibition Augment Nonoverlapping Features of T Cell Activation in Cancer

    Scientists performed single-cell RNA-sequencing and T cell receptor clonotype tracking of breast and ovarian cancer patients treated with the CDK4/6 inhibitor ribociclib and PD-1 blockade.
    [Journal Of Experimental Medicine]

    Full Article

    CD28-CAR-T Cell Activation through FYN Kinase Signaling Rather Than LCK Enhances Therapeutic Performance

    The authors found that LCK-deficient CAR-T cells were strongly signaled through CAR and had better in vivo efficacy with reduced exhaustion phenotype, as well as enhanced induction of memory and proliferation.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Spatially Resolved Transcriptomics Reveals Pro-Inflammatory Fibroblast Involved in Lymphocyte Recruitment through CXCL8 and CXCL10

    Investigators used single-cell RNA sequencing, spatial transcriptomics, and high-resolution multiplex fluorescence in situ hybridisation to characterise human oral mucosa in health and oral chronic inflammatory disease.
    [Elife]

    Abstract

    Distinct Clonal Identities of B-ALLs Arising after Lenolidomide Therapy for Multiple Myeloma

    Samples from 17 patients with multiple myeloma treated with lenalidomide, who subsequently developed B-cell acute lymphoblastic leukemia (B-ALL) were evaluated through sequencing, cytogenetics/fluorescence in situ hybridization, immunohistochemical staining, and immunoglobulin heavy chain clonality assessment.
    [Blood Advances]

    Full Article
    Graphical Abstract
    Take the Immunology Podcast feedback survey for a chance to win a Bluetooth speaker.
    REVIEWS

    Facts and Hopes in Immunotherapy for Early-Stage Triple-Negative Breast Cancer

    The authors review the current challenges and future aspirations for immunotherapy treatments for early-stage triple-negative breast cancer patients.
    [Clinical Cancer Research]

    Abstract

    Glomerulonephritis: Immunopathogenesis and Immunotherapy

    The authors present the immunopathogenesis of glomerulonephritis (GN) and immunotherapies in use and in development, and discuss how an immunopathogenesis-based GN classification can focus research, and improve patient management and teaching.
    [Nature Reviews Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Roche’s Tecentriq Plus Avastin Combination Reduced the Risk of Cancer Returning in People with Certain Types of Early-Stage Liver Cancer in a Phase III Trial

    The Phase III IMbrave050 study investigating Tecentriq plus Avastin in people with early-stage hepatocellular carcinoma at high risk of recurrence following surgery met the primary endpoint of recurrence-free survival.
    [Roche]

    Press Release
    FEATURED EVENT

    Next Generation Antibody Therapeutics: From Discovery to Patient

    February 19 – 22, 2023

    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – CAR T Immunotherapy

    Imperial College London – London, England, United Kingdom

    Associate Professor – Neuroimmunology & Neuroinflammation

    The University of Luxembourg – Belval, Luxembourg

    Sheila Joan Smith Professorship – Immunology

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Scholar Position – Cancer Drug Resistance

    University of California Los Angeles – Los Angeles, California, United States

    Research Chair – Immunology

    The University of Edinburgh – Edinburgh, Scotland, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter