Human Immunology News Volume 11.05 | Feb 7 2023

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    Laurisa Dohm
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    2023-02-07 | HIN 11.05


    Human Immunology News by STEMCELL Technologies
    Vol. 11.05 – 7 February, 2023
    TOP STORY

    Single-Cell Spatial Immune Landscapes of Primary and Metastatic Brain Tumors

    Researchers applied imaging mass cytometry to characterize the immunological landscape of 139 high-grade glioma and 46 brain metastasis tumors from patients, including single-cell analysis of more than 1.1 million cells across 389 high-dimensional histopathology images.
    [Nature]

    Full ArticlePress Release
    SepMate™ PBMC Isolation
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell and Spatial Transcriptomics Reveal Aberrant Lymphoid Developmental Programs Driving Granuloma Formation

    The authors performed single-cell sequencing and spatial transcriptomics on granulomas from patients with sarcoidosis, and bioinformatically reconstructed the underlying gene regulatory networks.
    [Immunity]

    AbstractGraphical Abstract

    Noncanonical Splicing Junctions between Exons and Transposable Elements Represent a Source of Immunogenic Recurrent Neo-Antigens in Patients with Lung Cancer

    Scientists compared human non–small cell lung cancer and diverse healthy tissues, and identified a subset of splicing junctions that were both tumor specific and shared across patients.
    [Science Immunology]

    Full Article

    NRF2 Activation Reprogrammes Defects in Oxidative Metabolism to Restore Macrophage Function in COPD

    Alveolar and peripheral monocyte-derived macrophages from chronic obstructive pulmonary disease (COPD) and healthy donors underwent functional, metabolic and transcriptional profiling, in an effort to establish if intrinsic defects in core metabolic processes drove macrophage dysfunction and redox imbalance.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract

    PD-L1 Translocation to the Plasma Membrane Enables Tumor Immune Evasion Through MIB2 Ubiquitination

    Investigators showed that mind bomb homolog 2 (MIB2) was required for PD-L1 transportation from the trans-Golgi network to the plasma membrane of cancer cells.
    [Journal Of Clinical Investigation]

    Full ArticleGraphical Abstract

    Myelodysplastic Syndrome Associated TET2 Mutations Affect NK Cell Function and Genome Methylation

    Researchers showed that patients with Myelodysplastic syndromes clones harbouring mutations in the TET2 gene were characterised by phenotypic defects in their circulating NK cells.
    [Nature Communications]

    Full Article

    Deletion of SNX9 Alleviates CD8 T Cell Exhaustion for Effective Cellular Cancer Immunotherapy

    Using a targeted pooled CRISPR-Cas9 screen and individual gene knockout validation experiments, the authors uncovered sorting nexin-9 (SNX9) as a mediator of T cell exhaustion.
    [Nature Communications]

    Full ArticlePress Release

    A Small-Molecule Drug Inhibits Autophagy Gene Expression through the Central Regulator TFEB

    Investigators showed that an US FDA-approved drug Eltrombopag bound to the basic helix-loop-helix-leucine zipper domain of transcription factor EB (TFEB), and disrupted TFEB-DNA interaction in vitro and in cellular context.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    STING Agonism Turns Human T Cells Into Interferon-Producing Cells but Impedes Their Functionality

    Scientists showed that the cGAS-STING pathway was indeed functional in human primary T cells. In the presence of a TCR-engaging signal, both cGAS and STING activation switched T cells into type I interferon-producing cells.
    [Embo Reports]

    Full ArticleGraphical Abstract
    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Locally Sourced: Site-Specific Immune Barriers to Metastasis

    The author discusses how site-specific differences of the immune system might be a major selective growth restraint on disseminated tumour cells, and argues that harnessing tissue immunity will be essential for the next stage in immunotherapy development that reliably prevents the establishment of metastases.
    [Nature Reviews Immunology]

    Full Article

    Antibody–Drug Conjugates: In Search of Partners of Choice

    Researchers review various antibody–drug conjugate( ADC)-based treatment combinations, and highlight that the most appealing partners for ADCs are those that offer additive or synergistic effects on tumor cells or their microenvironment, without unacceptable overlapping toxicities.
    [Trends In Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Ankyra Therapeutics Announces Collaboration to Evaluate ANK-101 in Early Clinical Trials Focused on Lung Cancer

    The collaboration will focus on the advancement of Ankyra’s lead product candidate, ANK-101, an IL-12-based locally administered immunotherapy, as a potential treatment for lung cancer.
    [Ankyra Therapeutics]

    Press Release
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